Barbara Alving, MD, MACP Director National Center for Research Resources

1. National Center forResearch Resources A c c e l e r a t i n g a n d e n h a n c i n g r e s e a r c h f r o m b a s i c d i s c o v e r y t o i m p r o v e d p a t I e n t c a r e NATIONAL INSTITUTES OF HEALTH Building a New Environment for Translational Research January 22, 2010 Barbara Alving, MD, MACP Director National Center for Research Resources

2. The Translation Gap Source: Butler D. Translational research: Crossing the valley of death. Nature. 2008;453:840–2.

3. National Health Expenditures as a Percent of GDP 20% Actual Projected 18% 16% 14% Percent of U.S. GDP 12% 10% 8% 1980 1982 1985 1988 1991 1994 1997 2000 2003 2006 2009 2012 2015

4. Impetus for the CTSA Program To ensure new discoveries lead to improved public health, clinical science must evolve to better: • Implement biomedical discoveries • Develop, test, and bring new prevention strategies into medical practice more rapidly • Catalyze change - lower barriers between disciplines • Encourage creative and innovative approaches www.CTSAWeb.org

5. CTSA National Strategic Plan Priorities Five strategic goals to enhance: • National clinical and translational research capability • Training and career development of clinical and translational scientists • Consortium-wide collaborations • Health of our communities and the nation • T1 translational research

6. National Center for Research Resources Translating research from basic discovery to improved patient care animal model resources community engagement science education Pre-clinical Improved patient care Community technology & informatics advances research capacity & training Clinical clinical research support

7. WA ME MT ND VT OR MN NH WI ID SD NY MA MI WY RI PA IA NE NV OH MD IN DE IL UT CO WV KS VA CA MO KY NC TN OK AR AZ SC NM GA AL MS AK TX LA FL HI Building a National CTSA Consortium 46 CTSA sites in 26 states;60 sites when fully implemented NJ = IDeA-Eligible States PR = CTSA State = IDeA-Eligible State and CTSA Member

8. = CTSA Institutions = East Coast Consortium = Midwest Consortium = West Coast Consortium CTSA – Creating Regional Partnership Opportunities Mayo Clinic College of Medicine Universityof Iowa University of Washington University of Chicago University of Wisconsin Oregon Health & Science University University of Rochester Yale University University of California, Davis Weill Cornell Medical College Columbia University University of California, San Francisco Rockefeller University Albert Einstein College of Medicine Stanford University The Scripps Research Institute Washington University in St. Louis

9. CTSAs – Home for Clinical and Translational Science

10. Kaiser Permanente Georgia CDC Yerkes National Primate Research Center Emory University Georgia Tech Morehouse School of Medicine Children’s Healthcare of Atlanta Complex Carbohydrate Research Center at U Georgia Atlanta VAMedical Center Georgia Research Alliance Georgia Bio CTSA – Providing Local Leveraging Opportunities Atlanta Clinical and Translational Science Institute (Atlanta-CTSI) at Emory University

11. CTSA program served as the catalyst that connected Scripps to Qualcomm and other technology firms Scripps and other CTSAs are conducting a 1,200-patient randomized clinical trial to evaluate a wireless monitor (size of large adhesive bandage) that monitors heart and breathing rates, fluid status, posture, and activity data in patients CTSA Translational ProjectsThe Scripps Translational Science Institute Pioneers Wireless Health Care Research Scripps Translational Science Institute has partnered with wireless telecommunications company Qualcomm to use wireless technology to decrease health care cost

12. Research Networking at Harvard CTSAHarvard Catalyst The Harvard Catalyst is a shared enterprise of Harvard University, its ten schools and its18 Academic Healthcare Centers, as well as numerous public, private and community partners

13. CTSA Industry Forum: Promoting Efficient and Effective Collaborations Among Academia, Government and Industry • CTSA wide meeting with industry and • non-profit groups • Exploring business practices and best management models in developing collaborations in the pre-competitive space • Looking to develop workgroups to address barriers to collaboration after conference is over • Engaging both the private and non-profit sector to identify gaps and opportunities for partnership and collaboration with CTSA institutions. February 17-18, 2010 Natcher Conference CenterBuilding 45, Main AuditoriumNIH Campus http://www.ncrr.nih.gov/CTSA_2010_Forum

14. Public-Private Partnerships (PPP) Example:The West Coast Licensing Partnership • Adds value by bundling related technologies over individual tools and technologies • Strengthens inter-institutional relationships between member partners • Increases global access to research tools by promotion of non-exclusive licensing • Provides simple one-stop licensing of technologies from multiple institutions • Saves time and money from negotiating multiple license agreements Oregon CTSA is part of a group of institutions willing to designate a subset of their technologies for marketing and licensing purposes

15. CTSA Consortium – Building Connections with Business Schools • Develop business plans, design, and implement community surveys • Create innovative cross-educational programs • Develop case studies to pilot programs • Collaborate with international colleagues • Prepare cost analyses • Protect CTSA-developed patents • Form industry partnership programs CTSA are partnering with business schools to:

16. Biomedical Technology Research Centers • Imaging • Technology • MRI • Image-guided therapy • PET • CAT • Ultrasound Informatics Resources • Genetics • Modeling of complex systems • Molecular dynamics • Visualization • Imaging informatics Optics & Laser Technology • Microscopy • Fluorescence spectroscopy • In Vivo diagnosis • 52 Unique Centers classified in 5 Broad Areas • Scope: from basic discovery to clinical research • Scale: from molecule to organism Technology for Structural Biology • Synchrotron x-ray technologies • Electron microscopy • Magnetic resonance Technology for Systems Biology • Mass spectrometry • Proteomics • Glycomics & glycotechnology • Flow cytometry

17. WA ME MT ND VT OR MN NH WI ID NY MA SD CT WY RI MI NJ PA IA NE NV OH MD IN DE IL UT CO WV KS VA CA MO KY NC TN OK AZ AR SC NM GA AL MS LA TX AK FL HI PR Institutional Development Award (IDeA)Increasing research capacity in 23 underserved states and Puerto Rico Montana State University Universityof Idaho • Lariat Project: • High Speed internet connectivity • Bridging digital divide University of Wyoming University of Nevada, Reno Universityof Hawaii Universityof Alaska = Lariat Project: encircling institutions with connectivity = IDeA-eligible states

18. Institutional Development Awards (IDeA) Northeast Cyberinfrastructure Consortium Improving Research Connectivity in the Northeast Collaborative research effort in five IDeA states to provide access to nationwide research networks and resources • Enhances the connectivity of networks at research institutions in underserved states can participate in data-intensive science applications • Enhance participation in NCRR programs at IDeA institutions located in these five states • Facilitates multi-institution research collaborations across the northeast These network upgrades will allow real time data transfer among researchers in the region.

19. Louisiana Optical Network Initiative (LONI) • Fiber optics network connecting supercomputers at major research universities in Louisiana • Led Governor to pledge more than $40 million over 10 years to support LONI • Results: scientific discoveries, new intellectual properties, and improved patient care and education Economic Impact: Several Louisiana academic institutions attracted over $110 million in new awards from the NIH

20. Institutional Development Award (IDeA)South Carolina Regional Meeting Highlights from IDeA Regional Meeting (South Carolina) • Collaboration between SC CTSA, INBRE and COBRE • Increasing access to CTSA pilot project funds • Developing statewide clinical research networks • Arkansas CTSA building a database of researchers and practicing physicians with the help of the Arkansas INBRE network • Arkansas’ eight HRSA-funded Area Health Education Centers (AHECs) • Providing community-based patient recruitment and exam sites for clinical studies • Co-located with INBRE partner institutions facilitating INBRE-CTSA-AHEC interactions/collaborations

21. Thomas Edison: A Design Thinker Design Thinking Methodology imbues the full spectrum of innovation activities with an understanding of what people want and need Edison’s Approach Team-based Multidisciplinary Good business sense Nimble budget Full product launch — light bulb, electric power system, etc. Source: Brown T. Design thinking. Harvard Business Review. June 2008.

22. Design Thinkers: Personality Profiles(Harvard Business Review June 2008, Tim Brown) Empathy • Look at work from multiple perspectives (colleagues, clients, end users, and customers) Integrative thinking • See salient and contradictory aspects of problem and find novel solutions Optimism • Assume that at least one potential solution is better than the existing alternatives Experimentalism • Pose questions and explore constraints in creative ways that proceed in entirely new directions Collaboration • Have significant experience in more than one discipline (engineers & marketers; anthropologists & industrial designers; architects & psychologists)

23. Aravind Eye Care System Largest and most productive eye care facility in the world Guiding Philosophy Aravind Eye Hospitals are named after Sri Aurobindo, one of the 20th century’s most revered spiritual leaders whose teachings focus on mankind’s transcendence into a heightened state of consciousness through service, as an instrument of what he called the Divine Force.

24. Taking a Global View of Design Thinking:Aravind Eye Care System in India More than an eye hospital Aravind is: • A social organization committed to the goal of elimination of needless blindness through comprehensive eye care services • An international training centre for ophthalmic professionals and trainees who come from within India and around the world • An institute for research that contributes to the development of eye care. • An institute to train health-related and managerial personnel in the development and implementation of efficient and sustainable eye care programs • A manufacturer of world class ophthalmic products available at affordable costs

25. Opportunities for Research and NIH Francis Collins • Applying high throughput technologies • Translating basic science discoveries into new and better treatments • Benefiting health care reform • Comparative effectiveness research • Prevention and personalized medicine • Health disparities research • Pharmacogenomics • Health research economics • Focusing on global health • Reinvigorating and empowering the biomedical research community 1 January 2010 Vol 327 Science, Issue 5961, Pages 36-37