1 / 1

Control of Gene Expression to Anticancer Drug Design and Development

+. Control of Gene Expression to Anticancer Drug Design and Development. Moses Lee Dean of Natural Sciences and Professor of Chemistry Tel: (616) 395-7190 Email: lee@hope.edu. Synthetic Methodology. Photograph. 2007 Group. Education:

garrett-potts
Download Presentation

Control of Gene Expression to Anticancer Drug Design and Development

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. + Control of Gene Expression to Anticancer Drug Design and Development Moses Lee Dean of Natural Sciences and Professor of Chemistry Tel: (616) 395-7190 Email: lee@hope.edu Synthetic Methodology Photograph 2007 Group Education: B.S., University of Guelph, Canada, 1983 Ph.D., University of Guelph, 1986 Medicinal Chemistry - Anticancer Drugs • Apoptosis induction • DNA interactive • Anti-angiogenesis • - Solid tumor • - Low toxicity • - Drug targeting • (ADEPT; ETPT) Areas of Expertise: Organic Chemistry, Synthesis, Biochemistry, and Medicinal Chemistry Grants and Awards: Spirogen Ltd. U.K., “Polyamide-PBD derivatives” Arnold Beckman Foundation, “Beckman Scholar” NSF, “Tuning the Thermodynamic and Kinetic Properties of the Binding of Hairpin Polyamides to Their Cognate DNA Sequences, through Incorporation of Intercalating and Threading Agents” GSK, "Design and Synthesis of Novel H-Pin Polyamides" DNA Sequence Specific Recognition • Medicine • Gene control • Anticancer drugs • -resistance • Diagnostics • Biosensors • -genetic disposition • -abnormal DNA • Homeland security Cell & animal biology Engineering • Molecule-DNA Complex • Sequence specificity • Structure and conformation • Molecular dynamics Key Publications and Presentations K.L. Buchmueller, S.L. Bailey,* D.A. Matthews,* Z.T. Taherbhai,* T. Brown, J. Register,* Z.S. Davis,* C.D. Bruce, B. Nguyen, W.D. Wilson, C. O’Hare, J.A. Hartley, and M. Lee, 2006, Physical and Structural Basis for the Strong Interactions of the –ImPy– Central Pairing Motif in the Polyamide, f-Im-Py-Im. Biochemistry45, 13551-13565. B. Purnell*, A. Sato, A. O’Kelley,* C. Price,* K. Summerville,* S. Hudson, C. O’Hare, K. Kiakos, J. A. Hartley, T. Asao andM. Lee,2006, DNA Interstrand Crosslinking Agents: Synthesis, DNA Interactions, and Cytotoxicity of Dimeric Achiral seco-amino-CBI and Conjugates of Achiral seco-Amino-CBI with Pyrrolobenzodiazepine (PBD). Bioorg. Med. Chem. Lett. 16, 5677-5681. (*Undergraduates) Molecular biology, biochemistry, biophysical, computational chemistry Design, synthesis

More Related