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LTP

LTP. Read pages 575 - 592. LTP. A persistent strengthening of synapses based on recent patterns of activity. review. Graded potential Action potential EPSP. Schaffer collaterals of CA3 pyramidals onto CA1 pyramidal.

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LTP

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  1. LTP Read pages 575 - 592

  2. LTP • A persistent strengthening of synapses based on recent patterns of activity.

  3. review • Graded potential • Action potential • EPSP

  4. Schaffer collaterals of CA3 pyramidals onto CA1 pyramidal. • If high frequency train of stimuli (AP) get LTP, evident as a long-lasting increase in EPSP amplitude. • LTP occurs in many other regions of the brain: cortex, amygdala, cerebellum

  5. LTP is state-dependent • LTP occurs when the post synpatic response is quick and large. • E.g. application of post synaptic current • The state of the membrane potential of the post synaptic cell. • Strong temporal linkage of pre and post synaptic events

  6. LTP input specificity • Only activated synapses are affected • Applies to memory.

  7. LTP is associative • In one pathway is weakly activated during stimulation, then that synapse will be strengthened as well. • Selective enhancement • Cellular analogue of associative learning, but expected of all neural networks

  8. LTP • State dependent - the NMDA receptor needs depolarization to remove Mg inhibition • Input specific -NMDA channels open only at stimulated synapses • Associative - the depolarization at the neighboring synapse can affect an non potentiated synapse.

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