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Reporter: Chun-Shuo Wang 2009. 10. 30 National Taiwan Normal University

Same blue dye in M&Ms linked to reducing spine injury PNAS July 28, 2009 vol. 106 no. 30 12489-12493. Reporter: Chun-Shuo Wang 2009. 10. 30 National Taiwan Normal University. Introduction. ATP accumulating in injured tissue. ATP associates with P2X7 causing cell death.

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Reporter: Chun-Shuo Wang 2009. 10. 30 National Taiwan Normal University

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  1. Same blue dye in M&Ms linked to reducing spine injuryPNAS July 28, 2009 vol. 106 no. 30 12489-12493 Reporter: Chun-Shuo Wang 2009. 10. 30 National Taiwan Normal University

  2. Introduction • ATP accumulating in injured tissue. • ATP associates with P2X7 causing cell death. • Extending injured site. ATP ATP ATP ATP → Cell Death P2X7 ATP ATP ATP

  3. Introduction • Inject oxidized ATP. • Block normal ATP to react with P2X7. • Difficult to use on human being. ATP(+) ATP(+) ATP(+) ATP(+) → Cell Safe! P2X7 ATP ATP(+) ATP(+)

  4. Method and Result • Inject BBG. • BBG bind with P2X7. • Good recovery(walk again with a limp) ATP BBG BBG BBG → Cell Safe! P2X7 ATP ATP BBG

  5. Discussion • Side effect: blue mice! • Further working to apply to humankind.

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