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HARMONY Study of Dementia in Swedish Twins

0. HARMONY Study of Dementia in Swedish Twins. health Hälsa genes ARv environment Miljö and Och new NY. NIA grant R01AG08724 and the Alzheimer’s Association. The Swedish Twin Registry. Old Cohort Born 1886-1925 (10,945 pairs) . Computer Assisted Telephone

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HARMONY Study of Dementia in Swedish Twins

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  1. 0 HARMONYStudy of Dementia in Swedish Twins • health Hälsa • genes ARv • environment Miljö • and Och • new NY NIA grant R01AG08724 and the Alzheimer’s Association

  2. The Swedish Twin Registry Old Cohort Born 1886-1925 (10,945 pairs) • Computer Assisted • Telephone • Interviews: • 1998-2001 Questionnaires: 1961, 1963, 1967 (1970) Middle Cohort Born 1926-1958 (13,665 pairs) • N = 20,269 • Individuals aged 65+ • (MZ, same sex DZ, • and • opposite sex DZ) Questionnaire: 1973

  3. HARMONY Screening Phase ALL TWINS 65+ 14,435 individuals SUSPECT NOT SUSPECT PARTNER TO NOT PARTNER DEMENTED NORMAL CONTROL SAMPLE NOT FOLLOWED DIAGNOSTIC WORKUP 0

  4. HARMONY Clinical Phase CLINICAL WORK UP 1557 individuals PRELIMINARY JUDGMENT CONSENSUS DIAGNOSTIC REVIEW DIAGNOSIS BOARD NEUROIMAGING FINAL CLINICAL DIAGNOSIS LONGITUDINAL AUTOPSY FOLLOW UP 0

  5. Swedish Twin Data for Studies of Cognitive Aging and Dementia Swedish Twin Registry HARMONY Old Middle SATSA SALZA Gender I Cohort Cohort OCTO-Twin 1970 1980 1990 2000

  6. 0 Registry Linkage Inpatient Psychiatric Registry

  7. Dependent Variable • Clinically diagnosed Alzheimer’s disease • Clinically diagnosed dementia • Cases screened as “suspects” and diagnosed with dementia • Controls screened as “not suspects” • “Cognitive dysfunction” • Screening outcomes • Registry diagnosed dementia

  8. Samples for Analysis of Dementia • Case-control • N = 547 cases, 12133 controls • Co-twin control • 140 pairs • Discordant MZ pairs • Enhanced by registry linkage • 106 twin pairs • Prospective dementia cohort

  9. Summary of published results • Basic description of study • Heritability • Cognitive screening • Age of onset • Early life risk factors • Occupation • Cancer • Education • Personality

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