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Kluk, K.*, Tan, C.M.*, Gilpin, H.*, Fitt N.*, John, M.S.**, Picton, T.W.**

MEASURING TRAINING-INDUCED AUDITORY PLASTICITY USING AUDITORY STEADY-STATE RESPONSES. Kluk, K.*, Tan, C.M.*, Gilpin, H.*, Fitt N.*, John, M.S.**, Picton, T.W.** * Human Communication and Deafness Research Group ,University of Manchester, Manchester,UK;

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Kluk, K.*, Tan, C.M.*, Gilpin, H.*, Fitt N.*, John, M.S.**, Picton, T.W.**

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  1. MEASURING TRAINING-INDUCED AUDITORY PLASTICITY USING AUDITORY STEADY-STATERESPONSES Kluk, K.*, Tan, C.M.*, Gilpin, H.*, Fitt N.*, John, M.S.**, Picton, T.W.** * Human Communication and Deafness Research Group,University of Manchester, Manchester,UK; **Rotman Research Institute, University of Toronto, Toronto, Canada E-mail: karolina.kluk@manchester.ac.uk

  2. INTRODUCTION Plasticity - re-mapping of the primary auditory cortex - may be induced by deprivation Kluk, K. and B.C. Moore, Dead regions in the cochlea and enhancement of frequency discrimination: Effects of audiogram slope, unilateral versus bilateral loss, and hearing-aid use. Hear Res, 2006. 222(1-2): p. 1-15.

  3. INTRODUCTION Plasticity - re-mapping of the primary auditory cortex - may be induced by deprivation or training.

  4. EXPERIMENTAL DESIGN Normally-hearing, right-handed, non-musicians R L R L Training Days 2, 3, and 4 ASSRs Day 1 ASSRs Day 5

  5. EXPERIMENT 1 L R L R L ASSRs Pitch Training ASSRs 1 2 kHz 1 kHz 1 2 Pure Tone 70 dBSPL 3 X 2 hours 100% AM 41 & 45 Hz 83 & 87 Hz the same as pre-training

  6. EXPERIMENT 1  Pure Tone results Training: 3 x 2-hour sessions, 24 hours apart 5000 presentations of pure tone at 1 kHz 3AFC

  7. EXPERIMENT 1  ASSR Amplitude

  8. EXPERIMENT 2 L R L R L ASSRs FM Training ASSRs 2 kHz 1 2 4 1 2 4 kHz FM Tone Modulated at 10 Hz 3 X 2 hours MM : 40 & 80 Hz the same as pre-training

  9. EXPERIMENT 2  FM results Training: 3 x 2-hour sessions, 24 hours apart 2- kHz FM tone modulated at 10-Hz 3AFC

  10. EXPERIMENT 2  ASSR Amplitude

  11. EXPERIMENT 3 R R L R L ASSRs AM Training ASSRs 2 kHz 1 2 4 1 2 4 kHz 1 2 4 1 2 4 kHz AM Tone Modulated at 4, 32, 128 Hz 3 X 2 hours 100 % AM 40 & 80 Hz the same as pre-training

  12. EXPERIMENT 3  AM results Training: 3 x 2-hour sessions, 24 hours apart 2- kHz AM tone 4, 32, 128 Hz 3AFC 4 Hz 32 Hz 128 Hz

  13. EXPERIMENT 3  ASSR Amplitude

  14. CONCLUSIONS • It is possible to measure training induced plasticity using ASSRs. • When Training using Pure Tones or Frequency Modulated Tones improvement on behavioural task is correlated with increased ASSR amplitude. • When training using Amplitude Modulated Tones there is no improvement on behavioural task nor an increase in ASSR amplitude.

  15. CONCLUSIONS 4. The increase of the ASSR amplitude after training may be caused by the reorganization of the primary auditory cortex and not by better synchronization of neural firing.

  16. Acknowledgements • Members and students of Human Communication and Deafness Research Group, Manchester, UK. • Faculty of Human and Medical Sciences Start-up Fund, The University of Manchester, UK E-mail: karolina.kluk@manchester.ac.uk

  17. Thank you ! E-mail: karolina.kluk@manchester.ac.uk

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