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Cell Membrane

Cell Membrane. Haixu Tang School of Informatics. Membrane Lipids Are Amphipathic Molecules. hydrophilic and hydrophobic molecules interact differently with water. Packing arrangements of lipid molecules. The spontaneous closure of a phospholipid bilayer. Phospholipid mobility.

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Cell Membrane

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  1. Cell Membrane Haixu Tang School of Informatics

  2. Membrane Lipids Are Amphipathic Molecules

  3. hydrophilic and hydrophobic molecules interact differently with water

  4. Packing arrangements of lipid molecules

  5. The spontaneous closure of a phospholipid bilayer

  6. Phospholipid mobility

  7. The other composition of membraneCholesterol and glycolipids It inhibits possible phase transitions: (1) decreases the permeability of the bilayer to small water-soluble molecules; (2) prevents the hydrocarbon chains from coming together and crystallizing.

  8. Cholesterol

  9. Glycolipid

  10. Four major phospholipids in mammalian plasma membranes

  11. Cell wall

  12. Lipid raft

  13. The asymmetrical distribution of phospholipids and glycolipids

  14. Functions of phospholipids in cell signaling

  15. Membrane proteins

  16. Membrane attachment of Water soluble proteins

  17. Transmembrane polypeptide chain crossing the lipid bilayer

  18. Using hydropathy plots to localize potential a-helical membrane-spanning segments

  19. b-barrels (occasionally)

  20. Solubilizing membrane proteins with a mild detergent

  21. Two detergent

  22. Reconstituting functional membrane protein system

  23. Red cell membrane

  24. Preparing red cell ghosts

  25. SDS polyacrylamide-gel electrophoresis pattern of the proteins in the human red blood cell membrane

  26. Three major ways of proteins association with membranes • Noncovalently Associated with the Cytosolic Side: Spectrin • Extends Through the Red Blood Cell Lipid Bilayer as a Single a Helix: Glycophorin • Multipass Membrane Protein: Band 3 protein

  27. Spectrin: cytoskeleton protein

  28. Spectrin-based cytoskeleton

  29. Glycophorin: single pass membrane proteins

  30. Band 3: Anion Transporter The polypeptide chain (about 930 amino acids long) is thought to extend across the bilayer 12 times.

  31. Photosynthetic reaction center

  32. The Cell Surface Is Coated with Sugar Residues

  33. Carrier proteins and channel proteins

  34. A typical ion channel

  35. The gating of ion channels

  36. Potassium ion gate

  37. Passive and active transport

  38. Three ways of driving active transport

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