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Infectious Diseases Unit 4 Lesson 4 plan

Infectious Diseases Unit 4 Lesson 4 plan. Do now. What are the two ways a pathogen causes damage?. Do now. What are the two ways a pathogen causes damage? Direct Indirect. Do now. What are the two ways a pathogen causes damage? Direct Indirect

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Infectious Diseases Unit 4 Lesson 4 plan

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  1. Infectious Diseases • Unit 4 Lesson 4 plan

  2. Do now • What are the two ways a pathogen causes damage?

  3. Do now • What are the two ways a pathogen causes damage? • Direct • Indirect

  4. Do now • What are the two ways a pathogen causes damage? • Direct • Indirect • What feature do both types of damage have in common?

  5. Do now • What are the two ways a pathogen causes damage? • Direct • Indirect • What feature do both types of damage have in common? • They cause host cell lysis

  6. Do now • Can you remember how bacterial pathogens make you sick? Today, we’ll consider how a virus damages a host (i.e. how it makes us sick!). • Let’s pretend a virus in our body is a lone soldier in enemy territory and one of our cells is a factory the soldier encounters. • How could the soldier use the factory if he was carrying building information?

  7. How do viruses make us sick? Do you remember the two ways bacteria cause damage? Viruses damage through their main goal: Making more viruses!

  8. But viruses need our cells to reproduce. The viral lifecycle has three stages: 1. Enter the cell 2. Replicate 3. Exit the cell

  9. Remember a virus needs to use a cell and evolution has molded this ability: First the virus attaches to the cell it is going to infect. Then the virusenters the cell. Surface receptors of HINI

  10. Replication strategies depend on the genetic code the virus has. • RNA viruses • DNA viruses

  11. Before we can learn how viruses replicate we need to remember molecular dogma! DNA RNA Protein

  12. Before we can learn how viruses replicate we need to remember molecular dogma! DNA RNA Protein Replication Transcription Translation Where in the cell do these processes take place?

  13. Before we can learn how viruses replicate we need to remember molecular dogma!

  14. DNARNAPROTEIN DNA viruses follow molecular dogma They need to get their DNA into the nucleus Herpesvirus is a DNA virus

  15. DNARNAPROTEIN DNA Viruses need host proteins to replicate Herpesvirus is a DNA virus

  16. RNARNAPROTEIN RNA viruses defy molecular dogma by makingRNAfrom RNA To do this they bring specialized enzymes with them H1N1 RNA viruses bring this enzyme with them

  17. RNADNARNAPROTEIN Retroviruses like HIV are RNA viruses They defy molecular dogma! They make DNA from RNA

  18. RNADNARNAPROTEIN Retroviruses defy molecular dogma by making DNA from RNA To do this they bring specialized enzymes with them Retroviruses bring the reverse transcriptase enzyme with them. They use an integrase, to insert the DNA into the host genome.

  19. RNA viruses cannot correct errors Random uncorrected mutations in RNA viruses cause Antigenic Drift

  20. Exit strategies • Can you remember the exit strategies for: • Naked viruses? • Enveloped viruses?

  21. Wrap up • How do virus make you sick? • Which strategy for survival is best for viruses? What is the most convincing evidence for your answer?

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