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Dive deep into enzyme inhibition with this informative guide covering functional and graphical features. Learn the types, mechanisms, and significance of enzyme inhibition. Explore key concepts explained by expert Eric Niederhoffer from SIU-SOM.
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k1 k2 S E k-1 -Km, Vmax 0.5Vmax Km Enzymes Eric Niederhoffer SIU-SOM S P E
EI S E Kic S + E ES E + P + I Kmapp/Vmax Kmapp -1/Kmapp Competitive Inhibition CI Competitive
ESI Kiu S + E ES E + P + I 1/Vmaxapp 0.5Vmax Kmapp/Vmaxapp Kmapp -1/Kmapp Uncompetitive Inhibition Uncompetitive (catalytic) UCI S E
EI ESI S E Kic Kiu S + E ES E + P + + I I 1/Vmaxapp Km/Vmaxapp 0.5Vmax Noncompetitive Inhibition NCI Noncompetitive (mixed-type) NCI S E
Enzyme Inhibition Summary Neat or what?
Review Questions • What is the function of enzymes? • What do enzyme names mean? • What are the types of enzyme inhibition (functional and graphical features)?