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Action of cardiotonic steroids eg ouabain, digoxin (cardiac glycosides)

[Na + ] cytosol. [Ca 2+ ] cytosol. contraction. Action of cardiotonic steroids eg ouabain, digoxin (cardiac glycosides). Na +. Ouabain. Na + /Ca 2+ Exchanger. Cytosol. Ca 2+. 2K +. 3Na +. Na + /K + ATPase. Cardiotonic steroids increase the force of

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Action of cardiotonic steroids eg ouabain, digoxin (cardiac glycosides)

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  1. [Na+]cytosol [Ca2+]cytosol contraction Action of cardiotonic steroids eg ouabain, digoxin (cardiac glycosides) Na+ Ouabain Na+/Ca2+ Exchanger Cytosol Ca2+ 2K+ 3Na+ Na+/K+ ATPase Cardiotonic steroids increase the force of contraction in the heart by inhibiting the Na+/K+ ATPase. Used to treat cardiac insufficiency or fibrillation Heart Cell

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