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Sofosbuvir + Ribavirin to Prevent Post-Transplant HCV Recurrence

Phase 2. Liver Transplantation. Treatment Naïve and Treatment Experienced. Sofosbuvir + Ribavirin to Prevent Post-Transplant HCV Recurrence. Curry MP, et al. Gastroenterology. 2014;September 24. [ Epub ahead of print]. Sofosbuvir + Ribavirin to Prevent Post-Transplant HCV Recurrence.

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Sofosbuvir + Ribavirin to Prevent Post-Transplant HCV Recurrence

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  1. Phase 2 Liver Transplantation Treatment Naïve and Treatment Experienced Sofosbuvir + Ribavirin to Prevent Post-Transplant HCV Recurrence Curry MP, et al. Gastroenterology. 2014;September 24. [Epub ahead of print]

  2. Sofosbuvir + Ribavirin to Prevent Post-Transplant HCV Recurrence Source: Curry MP, et al. Gastroenterology. 2014;September 24. [Epub ahead of print]

  3. Sofosbuvir + Ribavirin to Prevent Post-Transplant HCV RecurrenceStudy Design 92 screened 63 enrolled 61 dosed 46 underwent liver transplantation 43 with HCV RNA <LLOQ at transplantation These 43 patients analyzed for post-transplant virologic response Source: Curry MP, et al. Gastroenterology. 2014;September 24. [Epub ahead of print]

  4. Sofosbuvir + Ribavirin to Prevent Post-Transplant HCV RecurrenceStudy Design 0 12 24 48 Post-12 Week Required Duration Liver Transplant Sofosbuvir + Ribavirin N = 61 SVR12 Treatment for 12 to 48 weeks while awaiting liver transplant Drug DosingSofosbuvir: 400 mg once dailyRibavirin (weight-based and divided bid): 1000 mg/day if < 75 kg or 1200 mg/day if ≥ 75 kg Source: Curry MP, et al. Gastroenterology. 2014;September 24. [Epub ahead of print]

  5. Sofosbuvir + Ribavirin to Prevent Post-Transplant HCV Recurrence Source: Curry MP, et al. Gastroenterology. 2014;September 24. [Epub ahead of print]

  6. Sofosbuvir + Ribavirin to Prevent Post-Transplant HCV Recurrence Virologic Response at Transplant and Post-Transplant 43/46 30/43 Source: Curry MP, et al. Gastroenterology. 2014;September 24. [Epub ahead of print]

  7. Sofosbuvir + Ribavirin to Prevent Post-Transplant HCV Recurrence Virologic Response at Transplant and Post-Transplant 43/46 31/43 31/43 30/43 Data for the 43 patientswith HCV RNA <25 IU/mL at time of transplant Source: Curry MP, et al. Gastroenterology. 2014;September 24. [Epub ahead of print]

  8. Sofosbuvir + Ribavirin to Prevent Post-Transplant HCV Recurrence Source: Curry MP, et al. Gastroenterology. 2014 September 17. [Epub Ahead of Print]

  9. Sofosbuvir + Ribavirin to Prevent Post-Transplant HCV RecurrenceConclusions Source: Curry MP, et al. Gastroenterology. 2014;September 24. [Epub ahead of print]

  10. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Onlinewww.hepatitisc.uw.edu Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.

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