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Invasive vs. Selective strategy NSTEMI

Invasive vs. Selective strategy NSTEMI. Objective: To determine whether a routine invasive (RI) strategy reduces the long-term frequency of cardiovascular death or nonfatal MI using a meta analysis of individual data from FRISC II , ICTUS an RITA-3 trials.

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Invasive vs. Selective strategy NSTEMI

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  1. Invasive vs. Selective strategy NSTEMI Objective: To determine whether a routine invasive (RI) strategy reduces the long-term frequency of cardiovascular death or nonfatal MI using a meta analysis of individual data from FRISC II, ICTUS an RITA-3 trials. Study: Pooled analysis of individual data with 5 years outcomes. Population: NSTEMI patients enrolled in FRISC II, ICTUS and RITA-3 trials. Endpoint: Composite ofcardiovascular (CV)death or non-fatal MI.

  2. Invasive vs. Selective strategy NSTEMI RandomisedN=5467 EarlyInvasive Angiography24h-7d ± revasc N=2721 SelectivelyInvasive Medicalstabilization Revascifischemia, refractoryangina N=2746

  3. Invasive vs. Selective strategy NSTEMI Eventrate at 5 year (%) p=0.002 p=0.68 p=0.001 3 year HR 0.91 (0.71-0.93) 0.83 (0.68-1.01) 0.77 (0.65-0.90)

  4. Invasive vs. Selective strategy NSTEMI Conclusion: A routine invasive strategy reduces long-term rates of cardiovascular death or myocardial infarction. Fox et al. J Am CollCardiol 2010;55:2435-45

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