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Cardiovascular Trait (CVT) Consortium Patricia Munroe

Cardiovascular Trait (CVT) Consortium Patricia Munroe. Primary traits of interest. Hypertension. Cardiac arrhythmias (ECG). Heart Failure. Aims of the CVT consortium.

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Cardiovascular Trait (CVT) Consortium Patricia Munroe

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  1. Cardiovascular Trait (CVT) Consortium Patricia Munroe

  2. Primary traits of interest Hypertension Cardiac arrhythmias (ECG) Heart Failure

  3. Aims of the CVT consortium • To characterise a series of KO mouse models derived from genes selected from human GWAS studies and functional experimentation. • Specific objectives: • To establish whether the KO mouse has the CV phenotype we predicted based on gene selection. • To establish additional phenotypic deviations from normal, including target-organ damage to heart, brain and kidney. • To characterise the functional consequences and pathways affected by absence of the KO gene.

  4. Consortium phenotype expertise and interests BP/hypertension/CAD ECG measures/arrhythmias New members Alistair Poole (UK) Tim Warner (UK) Cristiana Ruhrberg (UK) Ines Pineda-Torra (UK) Ross Breckenridge (UK) CVT consortium members are from UK, NL, FR and USA LVD, LVH and Heart Failure

  5. CV screening by IMPC

  6. Flow chart of the experiments

  7. Consortium secondary screens

  8. Consortium secondary screens

  9. Models and challenges

  10. Current activities • Developing packages of work for year 1 • How best to distribute CV phenotyping between centres? • Creation of working groups per gene of interest • Obtaining additional functional data on genes of interest for inclusion in grants • Funding options for technical staff and CV phenotyping • New member interests • Development of HT platelet phenotyping protocol (A. Poole), and a platelet aggregation assay (T. Warner) • Inclusion of CAD genes from GWAS (N. Samani) • Lipids and metabolomics (M. Ala-Korpela)

  11. Additional slides

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