1 / 13

An Essay on “The Chemical Basis of Morphogenesis” written by A. Turing

An Essay on “The Chemical Basis of Morphogenesis” written by A. Turing. Yongjin Park (99328-162), Dept. of Biological Sciences. Agenda. Morphogenetic model A critique on the article Conclusion regarding complexity. Morphogenetic Model.

gianna
Download Presentation

An Essay on “The Chemical Basis of Morphogenesis” written by A. Turing

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. An Essay on “The Chemical Basis of Morphogenesis” written by A. Turing Yongjin Park (99328-162), Dept. of Biological Sciences

  2. Agenda • Morphogenetic model • A critique on the article • Conclusion regarding complexity

  3. Morphogenetic Model • Morphogenesis := morphology (shape) + genesis (development) • Chemical reagent (I.e., hormones) matters • Enzyme kinetics: velocity ∝ concentration • Osmotic pressure as driving force • Cell as a single system • Morphogen as a single unit • Units ∈ System

  4. Morphogenetic Model cont. Model organism (hydra)

  5. Morphogenetic Model cont. X Y

  6. A critique on Turing • Mathematically rigorous model but not biologically relevant. • Physical basis simultaneously contributes to the morphogenesis in more fundamental aspects. • Skeletal structures (both extra and intra) • Almost not permeable (or highly selective) cell membrane • Tightly controlled cell division cycle • Membrane tension • Cell migration (neural navigation) • A single cell is far more complex.

  7. Sui Huang &Donald E. Ingber, Nature Cell Biology1, E131 - E138 (1999)

  8. Sui Huang &Donald E. Ingber, Nature Cell Biology1, E131 - E138 (1999)

  9. MarcNeumann & MarkusAffolter, EMBO reports7, 1, 36–40 (2006)

  10. Olga C. Rodriguez et al., Nature Cell Biology5, 599 - 609 (2003)

  11. LucaTamagnone & PaoloM.Comoglio,EMBO reports5, 4, 356–361 (2004)

  12. Cellular network model X Y

  13. Conclusion • Simplicity within complexity • Oscillating chemical gradient is at the heart of biological homeostasis. • Morphogenesis or chemical computing • Chicken or egg problem • Physical complexity leads to computing structure • Network model of state machines • But even central dogma is not devised in 1950’s. • Biological state machine  DNA computing.

More Related