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Dr. Horst Hemmerle

Dr. Horst Hemmerle. Eli Lilly & Company Director Lead Generation Technologies: Responsible for: Compound Collection Enrichment Strategy Screening Strategies – Target families DCRT Technologies /Automation Chemoinformatics/Chemogenomics. Solving Complex Issues. Prostate Cancer.

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Dr. Horst Hemmerle

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  1. Dr. Horst Hemmerle Eli Lilly & Company Director Lead Generation Technologies: Responsible for: Compound Collection Enrichment Strategy Screening Strategies – Target families DCRT Technologies /Automation Chemoinformatics/Chemogenomics

  2. Solving Complex Issues Prostate Cancer Disease mechanism Cellular mechanism Angiogenesis Apoptosis Informatcis platforms allow integration and creation of knowledge VEGF FAS Molecular mechanism compounds Annotated chemical diversity Targets Analysis – Predictions - Simulations

  3. Ideal Drug Properties Kinases GPCRs NHRs Structural Novelty Library Deliverables • Hits/Leads/Back-up Scaffolds MTS of selected cassettes forDrug Discovery efforts • Validation Tools (Hits,Fragments) • Ligands to Explore Polypharm Selected sets forTarget of Interest evaluation Dynamic Library compounds data Iterative Screen Panels Kinases GPCRs NHRs Ion Channels Proteases Lipases Transporters Active Compounds and Information

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