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ENHANCE. Mean carotid IMT 0.0058 ± 0.0037 mm in the simvastatin arm vs. 0.0111 ± 0.0038 mm in the ezetimibe/simvastatin arm (p = 0.29) Mean LDL levels 192.7 mg/dl (39% ↓ ) in simvastatin arm, 141.3 mg/dl in the ezetimibe/simvastatin arm (56% ↓ ) (p < 0.01). (p = 0.20). (p < 0.01).
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ENHANCE Mean carotid IMT 0.0058 ± 0.0037 mm in the simvastatin arm vs. 0.0111 ± 0.0038 mm in the ezetimibe/simvastatin arm (p = 0.29) Mean LDL levels 192.7 mg/dl (39% ↓) in simvastatin arm, 141.3 mg/dl in the ezetimibe/simvastatin arm (56% ↓) (p < 0.01) (p = 0.20) (p < 0.01) Ezetimibe/ Simvastatin (n = 357) Simvastatin (n = 363) Trial design:Patients with heterozygous familial hypercholesterolemia were randomized to treatment with ezetimibe/simvastatin 10/80 mg or simvastatin 80 mg alone. Mean change in intima-media thickness (IMT) was measured in the carotid arteries over 2 years. Results 4.7 5 193 4 200 2.8 141 3 150 % mg/dl 2 Conclusions 100 • No additional benefit in carotid IMT reduction at 2 years with ezetimibe/simvastatin compared with high-dose simvastatin alone • LDL lowering greater with ezetimibe/simvastatin • Clinical outcomes and adverse events similar 1 50 0 0 LDL cholesterol New plaque formation Kastelein JJ, et al. N Engl J Med 2008;358:1431-43
