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HIV Opportunistic infections

HIV Opportunistic infections. OIs- 10. OIs are the most common presentation of chronic treated HIV infection. OIs– 10. No. OIs - 20. OIs usually present when CD4< 300. OIs – 20. No usually when CD4 < 200. OIs - 30. The most common OI in HIV infection. OI – 30. Oral candidiasis.

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HIV Opportunistic infections

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  1. HIV Opportunistic infections

  2. OIs- 10 • OIs are the most common presentation of chronic treated HIV infection

  3. OIs– 10 • No

  4. OIs - 20 • OIs usually present when CD4< 300

  5. OIs – 20 • No usually when CD4 < 200

  6. OIs - 30 • The most common OI in HIV infection

  7. OI – 30 • Oral candidiasis

  8. OI - 40 • Name 2 of the most life threatening OIs

  9. OI– 40 • PCP • Cryptococcosis

  10. OI- 50 • CMV presents when CD4 < 50 and prophylaxis with antivirals should be started

  11. OI– 50 • Antivirals are not part of prophylaxis for HIV related OIs

  12. PCP - 10 • One of the most common causes of death from AIDS in 80s

  13. PCP – 10 • Yes

  14. PCP- 20 • PJP is a common environmental parasite

  15. MHC – 20 • IT is a fungus not a parasite

  16. PCP- 30 • Drug of choice for PCP prophylaxis and alternative if patient has allergy

  17. PCP– 40 • Diagnostic test of choice for PCP

  18. PCP- 40 • Diagnostic test of choice for PCP

  19. PCP– 40 • Sputum DFA for PCP

  20. PCP- 50 • One scenario that patient should stay on prophylaxis for PCP for life

  21. PCP– 50 • If patient had episode of PCP with CD4 > 200

  22. Cryptococcus- 10 • The most common manifestation of cryptococcus infection

  23. Cryptococcus– 10 • CNS infection

  24. Cryptococcus- 20 • Why frequent LPs are needed with crypto meningitis?

  25. Cryptococcus– 20 • Increased ICP

  26. Cryptococcus - 30 • Name two diagnostic tests for Cryptococcus infection

  27. Cryptococcus– 30 • Cryptococcus antigen • Fungal culture

  28. Cryptococcus - 40 • Name the induction therapy for Cryptococcus

  29. Cryptococcus– 40 • Amphotericin + 5FC

  30. Cryptococcus - 50 • This regimen has been used in resource poor countries for treatment of Cryptococcus infection

  31. Cryptococcus– 50 • High doses fluconazole (>800 mg) plus 5FC

  32. Toxoplasma- 10 • Name 2 presentation of toxoplasmosis

  33. Toxoplasma- – 10 • Fever, headaches, seizures, no clinical manifestations

  34. Toxoplasma - 20 • A common carrier of toxoplasma (animal)

  35. Toxoplasma– 20 • Cat

  36. Toxoplasma - 30 • The antibiotic that is used for prophylaxis for Toxoplasma is also effective for other OIs

  37. Toxoplasma– 30 • Bactrim is also effective against PCP

  38. Toxoplasma- 40 • Name alternative antibiotics for Toxoplasma (if there is allergy to the drug of choice)

  39. Toxoplasma– 40 • Clindamycin, pyrimethamine

  40. Toxoplasma- 50 • Duration of prophylaxis for toxoplasma

  41. Toxoplasma- 50 • Discontinue ppx when CD4>200 > 3 months

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