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Drosophila shows a prominent homeostatic response to sleep deprivation

30. 20. 10. 0. Drosophila shows a prominent homeostatic response to sleep deprivation. Baseline day 1+2 SD day (6h) Recovery day 1. Sleep min / 30 min. Fly sleep is modulated by stimulants and hypnotics. Caffeine. Hydroxyzine. 1A.

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Drosophila shows a prominent homeostatic response to sleep deprivation

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  1. 30 20 10 0 Drosophila shows a prominent homeostatic response to sleep deprivation Baseline day 1+2 SD day (6h) Recovery day 1 Sleep min / 30 min

  2. Fly sleep is modulated by stimulants and hypnotics Caffeine Hydroxyzine 1A Shaw PJ, Cirelli C, Greenspan RJ, Tononi G. Science, 2000 Modafinil Hendricks et al., Sleep 2003

  3. electrodes ground sensor laser heat lamp Fly sleep is accompanied by EEG changes Nitz DA, van Swinderen B, Tononi G, Greenspan RJ. Current Biology 12:1934-1940, 2002

  4. Fly sleep is characterized by changes in gene expression similar to those observed in mammals Cyt c oxysub 1 Cirelli and Tononi, Mol Brain Res, 1998; Cirelli, Gutierrez, Tononi, Neuron 2004

  5. Summary: Sleep in flies shares key featureswith sleep in mammals Like mammalian sleep, sleep-like states in Drosophila are: • consolidated into long period of quiescence • characterized by increased arousal thresholds • homeostatically regulated • modulated by stimulants and hypnotics • associated with changes in brain electrical activity • associated with changes in gene expression

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