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Amines & Proteins

Amines & Proteins. Physical Properties. Benzenamine & Heterocyclic Amines. Amines vs. Amides. Amides less basic than amines. Amines vs. Amides. Resonance stabilization due to pair of electrons Electron withdrawing effect of the carbonyl group. Biologically Important Amines.

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Amines & Proteins

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  1. Amines & Proteins

  2. Physical Properties

  3. Benzenamine & Heterocyclic Amines

  4. Amines vs. Amides Amides less basic than amines

  5. Amines vs. Amides • Resonance stabilization due to pair of electrons • Electron withdrawing effect of the carbonyl group

  6. Biologically Important Amines • 2-Phenylethylamines (P. 953) • Physiological & Psychological effects • Adrenaline, noradrenaline • Vitamins & Antihistamines • Vitamins B6, B1, Niacin • Histamine, Valium, Nicotine • Tranquilizers • Neurotransmitters • Acetylcholine (Ach)

  7. Reductive Amination

  8. Hinsberg Test • Used to differentiate between 10, 20 & 30 amines • 10 amines precipitate after Acidification • 20 amines precipitate after first stage • 30 amines no reaction

  9. Proteins • 4 Kcal / g • Subunit Amino Acids • Linked by Peptide Bonds (Condensation Reactions

  10. Major Functions • Enzymes: Biological catalysts • Antibodies: Fight infection • Transport: Move materials around Ex. hemoglobin for O2. • Regulatory: Hormones, control metabolism. • Structural: Coverings and support skin, tendons, hair, nails, bone. • Movement: Muscles, cilia, flagella.

  11. Primary Structure • Covalent Bonds (Peptide Bonds)

  12. Secondary Structure • H-bonds

  13. Tertiary Structure • All bond types • Functional Level

  14. Quandary Structure • Mixed Bonds • Two or more proteins working together (Synergy)

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