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Mohammad Farahmandnia M.D. Undergraduate Shiraz University of Medical Science Shiraz, Iran

Explore simultaneous observation of mTORC1 activity and ROS increase in aging, shedding light on the interplay between aging mechanisms. Review key theories and evidence supporting this link.

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Mohammad Farahmandnia M.D. Undergraduate Shiraz University of Medical Science Shiraz, Iran

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  1. ROS Might Just Be A SideshowExploring Simultaneous Observation of mTORC1 Activity and Increase in ROS • Mohammad Farahmandnia • M.D. Undergraduate • Shiraz University of Medical Science • Shiraz, Iran

  2. Part 1: Introduction

  3. Definition of Aging • As tangible is senescence to human perception, it has proven hard to define. • Decline in the function of different organs of the body (Iseghohi 2016) • Hyperfunction (Blagosklonny 2008)

  4. Diseases of Aging Farahmandnia 2016

  5. Impact of Aging • 6 out of 10 major causes of death strongly correlated with aging and their share of deaths in 2012. (WHO Factsheets 2012) Farahmandnia 2016

  6. Impact of Aging • When calculated cumulatively, 75% of deaths caused by major causes are to blame on diseases of aging. Farahmandnia 2016

  7. Prominent Theories of Aging • Damage Accumulation • Reactive Oxygen Species-centeric • emphasizes decline of function • Wear and Tear • ~ Stem Cell-centric • emphasizes decline of function • Quasi-programmed • ~ mechanistic Target of Rapamycin-centric • emphasizes Hyperfunction

  8. Getting to know mTOR • mTOR is the catalytic subunit of two distinct complexes called mTOR complex 1 (mTORC1) and mTORC2. Sabatini 2010

  9. Getting to know mTOR Sabatini 2010

  10. Getting to know mTOR Sabatini 2010

  11. Getting to know mTOR Johnson 2013

  12. Getting to know mTOR Johnson 2013

  13. Intentionally Blank

  14. Part 2: ROS

  15. Agenda • Fruits Are Effective, But Not by Reducing ROS • Basic Science Evidence • Clinical Evidence • “What-the-hell” Evidence!

  16. Fruits!

  17. Basic Science Evidence

  18. Basic Science Evidence

  19. Basic Science Evidence

  20. Clinical

  21. “WTH” Evidence!

  22. Intentionally Blank

  23. Part 3: mTOR-ROS Simultaneity

  24. ROS generation is downstream of mTOR

  25. ROS generation is downstream of mTOR

  26. Remember: ROS might not even be an effecter

  27. Suggesting an Alternative Mechanism with ROS as a Sideshow

  28. Collaborators: Aging Research Team: Mohammadreza Dorvash, Pharm.D. Mohammadhossein Khorraminejad-Shirazi, M.D. undergraduate Student Research Committee, Shiraz University of Medical Sciences Student Cell & Molecular Medicine Research Lab Director: Seyyed Mojtaba Hosseini M.D. Mentor: Iman Tavassoly M.D., Ph.D National Center for Systems Biology, Mount Sinai, New York

  29. Thank You for Your Attention • Any Questions? • farzamfarahmandnia@gmail.com

  30. Life Expectancy • Hand sanitation ~ 1850 • Antibiotics ~ 1930s

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