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Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)

Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). 5804 patients aged 70 –82 years with a history of vascular disease or with cardiovascular risk factors Randomized to pravastatin 40 mg/d or placebo Baseline TC 155–348 mg/dL Follow-up 3.2 years (mean)

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Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)

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  1. Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) • 5804 patients aged 70–82 years with a history of vascular disease or with cardiovascular risk factors • Randomized to pravastatin 40 mg/d or placebo • Baseline TC 155–348 mg/dL • Follow-up 3.2 years (mean) • Primary endpoint (composite): coronary death, nonfatal MI, fatal or nonfatal stroke Shepherd J et al. Lancet 2002;360:1623–1630.

  2. Kaplan–Meier Analysis of Time to Primary Endpoint: PROSPER Placebo Proportion with Event (%) Pravastatin p=0.014 0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 Follow-up (years) Number at RiskPlaceboPravastatin 29132891 28322812 27482738 26512655 25602562 24582483 21282167 730770 4440 Shepherd J et al. Lancet 2002;360:1623–1630. Reprinted with permission from Elsevier Science.

  3. Major Endpoints: PROSPER Shepherd J et al. Lancet 2002;360:1623–1630.

  4. Mortality by Cause: PROSPER Shepherd J et al. Lancet 2002;360:1623–1630.

  5. First New Cancer Diagnoses by Site: PROSPER Shepherd J et al. Lancet 2002;360:1623–1630.

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