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U05-18498 #3846771104

A 34-year-old with a history of hypertension, polycystic ovarian syndrome, gout, and obesity presents with flu-like symptoms, cough, and SOB. Lab results show proteinuria and renal impairment. Renal biopsy confirms postinfectious glomerulonephritis.

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U05-18498 #3846771104

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  1. U05-18498 #3846771104 34 years old from Vermilion referred with increasing Cr 730 baseline normal? Known to have: · HTN Dx 6 yrs ago on Coversyl and Atenolol· Polycystic ovarian syndrome, · Gout, · Obesity · Family Hx: Brother had IgA nephropathy S/P renal transplantC/O 2 weeks Hx of flue like symptoms, cough, sputum productionSOB, PND but no chest painNo skin rash or joint painOn exam: BP 150/90, O2 sat 94% on 5 L/min NRBM, LL oedemaLab: U/A: +3 protein, +3 Hb, WBC 1-5, RBC 26-50, Protein ~ 2 gm /day, Cr 730, K5.2, Co2 18, Cl 104,Na 139, HBV, HCV negative, ANA + speckled pattern, ANCA – negative, Anti-GBM negative, C3  0.27(0.8-2), C4  0.64 (0.8-0.36), ASO titre 1:680Throat swab + Strept pyogens

  2. IF • IgG- Mild mesangial staining • IgA- Mild mesangial staining with extension to peripheral capillary loops • IgM- Negative • C3- Trivial-mild capillary loop staining • C1q- Negative • Kappa- Negative • Lambda- Negative • Fibrin- Mild interstitial staining • Albumin- negative

  3. IgG

  4. IgA

  5. C3

  6. fibrin

  7. IgG

  8. IgG

  9. IgG

  10. IgG

  11. Diagnosis:Renal Biopsy:Postinfectious glomerulonephritis with severe proliferative changes

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