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BORDETELLA

BORDETELLA. K.V.PRAVEEN CHANDER. Important species. Bordetella pertussis - Bordet-Gengou bacillus Bordetella parapertussis Bordetlla bronchiseptica - ancestral form Bordetella avium -causes respiratory disease in turkeys. Virulence.

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BORDETELLA

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  1. BORDETELLA K.V.PRAVEEN CHANDER

  2. Important species • Bordetella pertussis- Bordet-Gengou bacillus • Bordetella parapertussis • Bordetlla bronchiseptica- ancestral form • Bordetella avium-causes respiratory disease in turkeys

  3. Virulence Steele, R.W. Pertussis: Is Eradication Achievable. Pediatric Annals. Aug 2004. 33(8):525-534

  4. Adhesions • Filamentous hemagglutinin • Pertactin • Fimbriae http://www.rivm.nl/infectieziektenbulletin/bul1306/kinkhoest.jpg http://www.my-pharm.ac.jp/~yishibas/research/Pertussis1.jpg

  5. Toxins • Pertussis Toxin • Adenylate Cyclase Toxin • Tracheal cytotoxin • Dermonecrotic toxin • Heat-labile toxin www.ibl.fr/u447/u447.htm

  6. Pertactin • Outer membrane protein antigen present in all virulent strains • Included in acellular pertussis vaccine

  7. Bordetella parapertussis • Infrequent, cause of whooping cough • Disease is mild • Pertussis vaccine do not give protection

  8. Bordetella bronchiseptica • Peritrichate flagella • Antigenetically related to pertussis and abortus • Occurs naturally in the respiratory tract of several sps of animals

  9. THANK YOU

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