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Cell Signaling Cascade: Phosphorylation, Hydrolysis, and Receptor Proteins

Learn about the intricate process of cell communication, where phosphorylation and hydrolysis events occur, involving receptor proteins and various signaling molecules. Understand the role of second messengers and their impact on cellular responses.

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Cell Signaling Cascade: Phosphorylation, Hydrolysis, and Receptor Proteins

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  1. AP Biology Cell Communication (Signaling) Part 2

  2. Phosphorylation and Hydrolysis

  3. Receptor Protein

  4. G protein Receptor

  5. Tyrosine – Kinase Receptor

  6. Gate closed Signal molecule (ligand) Ions Plasma membrane Ligand-gated ion channel receptor Ion Channel Receptors Gate open Cellular response Gate closed

  7. Intracellular receptors

  8. Secondary Messenger cAMP Phosphodiesterase Adenylyl cyclase Pyrophosphate H2O P P i ATP Cyclic AMP AMP

  9. First messenger (signal molecule such as epinephrine) Adenylyl cyclase G protein G-protein-linked receptor GTP ATP Second messenger cAMP Protein kinase A Cellular responses

  10. EXTRACELLULAR FLUID Signal molecule (first messenger) G protein DAG GTP Secondary Messenger Calmodulin G-protein-linked receptor PIP2 Phospholipase C IP3 (second messenger) IP3-gated calcium channel Cellular re- sponses Various proteins activated Endoplasmic reticulum (ER) Ca2+ Ca2+ (second messenger) CYTOSOL

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