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No Association between Body Composition and Cognition in Ambulatory Persons with Multiple Sclerosis

This brief report investigates the relationship between body composition and cognitive function in individuals with multiple sclerosis (MS). The study found no significant association between measures of body fat and cognitive outcomes. However, lean body mass was associated with cognitive processing speed, and bone mineral density was associated with cognitive processing speed and verbal learning and memory. These associations were attenuated after controlling for age and Expanded Disability Status Scale scores. The findings suggest that body composition may not be a target for interventions to improve cognitive function in MS.

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No Association between Body Composition and Cognition in Ambulatory Persons with Multiple Sclerosis

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  1. No association between body composition and cognition in ambulatory persons with multiple sclerosis: A brief report Brian M. Sandroff, MS; Elizabeth A. Hubbard, MS; Lara A. Pilutti, PhD; Robert W. Motl, PhD

  2. Aim • Investigate the associations between measures of body composition and domains of cognitive function in ambulatory persons with multiple sclerosis (MS). • Relevance • Evidence suggests body fat is inversely associated with cognitive functioning. • This association might further be augmented in presence of immune-mediated, inflammatory disease such as MS.

  3. Method • Cross-sectional study investigating associations between objective measures of body composition and cognitive function in 60 persons with MS. • Following tests performed: • Neurological examination for Expanded Disability Status Scale scores. • Brief International Cognitive Assessment in Multiple Sclerosis neuropsychological battery for measurement of cognitive processing speed, verbal learning and memory, and visual learning and memory. • Whole-body fat mass, percent body fat, lean body mass, and bone mineral density measured using dual-energy X-ray absorptiometry.

  4. Results • Whole-body fat mass and percent body fat not associated with any cognitive outcome. • Lean body mass associated with cognitive processing speed and bone mineral density associated with cognitive processing speed and verbal learning and memory. • Associations attenuated and nonsignificant after controlling for age and Expanded Disability Status Scale scores.

  5. Conclusion • Body composition might not represent a target of interventions for improving cognitive processing speed or learning and memory in MS.

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