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VUOS Photo tour

VUOS offers a wide range of services including laboratory testing, chemical synthesis, low-temperature production, phosgenation, hydrogenation, filtration, and warehouse storage.

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VUOS Photo tour

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  1. PARTNER FOR COOPERATION VUOSPhoto tour

  2. Buildings • 2 • VUOS – PARTNER FOR COOPERATION

  3. Buildings • 215 employess • Skilled – 25 % • Secondary – 30% • University degree – 36% • Ph.D. degree – 9% • 3 • VUOS – PARTNER FOR COOPERATION

  4. Laboratories • Analytical methods • NMR Spectrometry • Mass Spectrometry (LC/GC-MS) • ICP-AES • IR Spectrometry • Chromatography (HPLC, GC) • UV-VIS • 4 • VUOS – PARTNER FOR COOPERATION

  5. Laboratories • Toxicological tests • In vivo and in vitro tests according to the OECD or EU methods: • Acute toxicity • Skin and Eye irritation • Sensibilisation • Repeated dose toxicity • Reproductive toxicity • Carcinogenicity • Mutagenicity • 5 • VUOS – PARTNER FOR COOPERATION

  6. Kilolab – Multipurpose chemistry • 20x glass reactors, 100 l each • 6x glass lined reactors (200–1 500 l) • 2x evaporators 50 l / h • 4x stainless steel reactors (300–1 500 l) sufficient filtration and distillation capacity • 6 • VUOS – PARTNER FOR COOPERATION

  7. Low temperature production line • 1 x glass reactor 50 l cooled down to – 80 ˚C • 1x glasslined reactor for NaH reactions (250 l) • 3x glass reactors 100l for RLi, Grignard reactions • 7 • VUOS – PARTNER FOR COOPERATION

  8. Low temperature production line Reactors up to 630 l cooled down to – 80 ˚C 1x glass-lined reactor for NaHreactions (250 l) 3x glass reactors 100lcooleddown to – 40°C • 8 • VUOS – PARTNER FOR COOPERATION

  9. Low temperature production line • 9 • VUOS – PARTNER FOR COOPERATION

  10. Phosgenation • Reactors up to 1 600 l • 2x High performance rectification columns • Laboratory phosgenation units from 1 to 30 l • 10 • VUOS – PARTNER FOR COOPERATION

  11. Phosgenation • 11 • VUOS – PARTNER FOR COOPERATION

  12. Hydrogenation • 3x autoclaves 100 l each, 60, 120 and 130bar, up to 200 ˚C, Hastelloy C clad • 1x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad • 1x autoclave 700 l, 100 bar, 200 ˚C, stainless steel • 1x autoclave 1 000 l, 10 bar, 140 ˚C, stainlesssteel many autoclaves up to 10 l • 12 • VUOS – PARTNER FOR COOPERATION

  13. Hydrogenation • 13 • VUOS – PARTNER FOR COOPERATION

  14. Hydrogenation • 14 • VUOS – PARTNER FOR COOPERATION

  15. Filtration • Sufficient filtration capacity (nutsches, centrifuges) • 15 • VUOS – PARTNER FOR COOPERATION

  16. Filtration • 16 • VUOS – PARTNER FOR COOPERATION

  17. Centrifuge • 17 • VUOS – PARTNER FOR COOPERATION

  18. Venulet • 18 • VUOS – PARTNER FOR COOPERATION

  19. Reactors • 52x glass lined reactors, total vol. 85 000 l (500 – 6 000 l) • 16x stainless steel reactors, total vol. 29 000 l (1 000–6 000 l) • 8x High performance rectification columns • sufficient filtration capacity (nutsches, centrifuges) • computer controlled • 19 • VUOS – PARTNER FOR COOPERATION

  20. Reactors • 20 • VUOS – PARTNER FOR COOPERATION

  21. Reactors • 21 • VUOS – PARTNER FOR COOPERATION

  22. GMPProduction Line certified since 2015 • Production of API • Starting materials and advanced intermediates • Controlled finalization of final products • Glass-lined vessels 400 and 630 l • Stainless steel vessels 400 and 630 l • Filtration, Centrifuging and Drying VUOS - PARTNER FOR COOPERATION

  23. GMPProduction Line certified since 2015 VUOS - PARTNER FOR COOPERATION

  24. New Production Unit dedicated for production of Pharma Intermediates • Purpose • Dedicated for the production of pharma intermediates under GMP standard • 5 reactors , total volume 10 000 l, stainless steel and glasslined • Filtration, distillation, drying • Ready in the year 2018 • 24 • VUOS – PARTNER FOR COOPERATION

  25. New Unit dedicated for grinding, drying and blending of dry materials • Purpose • Dedicated for the for grinding, blending and drying of pharma intermediates under GMP standard • 3 tray dryers in separate rooms with separate ventilation • Equipment for grinding and blending • 25 • VUOS – PARTNER FOR COOPERATION

  26. Warehouse • 26 • VUOS – PARTNER FOR COOPERATION

  27. Warehouse • 27 • VUOS – PARTNER FOR COOPERATION

  28. Warehouse • 28 • VUOS – PARTNER FOR COOPERATION

  29. Výzkumný ústav organických syntéz a.s. • Rybitví č.p. 296, 533 54 Rybitví, Czech Republic • www.vuos.com

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