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Cells of the Immune System

Cells of the Immune System. Lymphocytes (derived from lymphoid progenitor). Large, granular. Mononuclear Phagocytes. Granulocytes Neutrophils: Phagocytes First to arrive at problem Eosinophils: Phagocytes Defense against parasites? Basophils: Nonphagocytic

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Cells of the Immune System

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  1. Cells of the Immune System

  2. Lymphocytes (derived from lymphoid progenitor) Large, granular

  3. Mononuclear Phagocytes Granulocytes Neutrophils: Phagocytes First to arrive at problem Eosinophils: Phagocytes Defense against parasites? Basophils: Nonphagocytic Allergies  Dendritic cells: Diverse functions Antigen capture Antigen presentation

  4. B cell differentiation after Ag encounter

  5. Characterized by highly packed chromatin

  6. Note large amounts of ER Why??

  7. mononuclear phagocyte— develops into macrophage

  8. Macrophage Also Fc receptors bind circulating ab-ag complexes further activation. This process is called opsinization

  9. Also a phagocyte— may help against parasites

  10. Involved in allergic responses

  11. Diagram of a x-section of the thymus

  12. Lymphatic system

  13. Structure of a Lymph Node

  14. Spleen

  15. Intestinal mucous membrane x-section

  16. endocytosis

  17. Evolution of lymphoid tissues

  18. 3.7 x 1011 cells produced/day!

  19. Programmed cell death Injury

  20. Clonal expansion B cell differentiation after Ag encounter

  21. Evolution of lymphoid tissues

  22. bacteria Monocyte Macrophage Pseudopodidia

  23. Inflammatory Response

  24. Recognize peptidoglycan fragments NOD: Nucleotide binding oligomerization domain

  25. Toll-like receptors Originally indentified in Drosophila Binds to LPS Identified in mice by Bruce Beutler Similar to domain on the IL-1 receptor

  26. In neutrophils and macrophages These act as antimicrobials Inducible nitric oxide synthetase (iNOS): Induced by receptors suchas TLRs or exposure to cytokines by phagocytes L-arg + O2 + NADPH  NO + L-citrulline + NADP+

  27. Signal Transduction

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