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Design and Development of a Discrete Simulation for Optic Nerve Development

This project focuses on the design and development of a discrete simulation for optic nerve development, aiming to understand the micro-environmental interactions that contribute to the development and repair of the central nervous system. The project involves the implementation of a data structure in Microsoft Access, modeling elements such as axons, oligodendrocytes, and astrocytes.

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Design and Development of a Discrete Simulation for Optic Nerve Development

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  1. Design and Development of a Discrete Simulation for Optic Nerve Development By: Brent Hefty Gregory P. Tevis Project Advisor: Samuel F. Hunter, M.D., Ph. D.

  2. Overall Purpose • Development and Repair of the Central Nervous System as a Function of Micro-environmental Interactions.

  3. Components of Model • Elements contained in the system. • Function of the elements in the system. • Data Structure to be implemented in Microsoft Access. • Future plans for implementation.

  4. Elements in Model • Axons • Magnocellular (large) • Parvocellular (small) • Oligodendrocytes • neonatal/adult • intermediate • myelinating • Astrocytes

  5. Function and Background • Structure of the optic nerve. • Oligodendrocyte life cycle. • Astrocyte life cycle.

  6. Axon Table • Axon ID • Magnocellular/Parvocellular • Position (X,Y,Z) • Diameter • Trophic Properties (optional) • Chemokinetic Properties (optional) • Final Segment • Index to Myelin Sheaths

  7. Oligodendrocyte Table • Oligodendrocyte ID • Oligodendrocyte Type • Position of Cell Body • Size of Cell Body • Number of Myelin Sheaths

  8. Myelin Table • Myelin ID • Position (X, Y, Z) • Thickness Length • Oligodendrocyte ID • Axon ID

  9. Astrocyte Table • Astrocyte ID • Type • Cell Body Position • Cell Body Size • Number of Processes

  10. Astrocyte Process Table • Process ID • Position (X, Y, Z) • Thickness (X, Y) • Astrocyte ID

  11. Completed: initial research development of proposed data structure construction of tables in Microsoft Access initial web page developed Future: research on software to be used define field items in tables define parameters and rules to be considered in development develop algorithm to model development (time permitting) complete web page Status Report Summary

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