1 / 10

Polymers In Pharmaceuticals

Polymers In Pharmaceuticals. Makenzie Ball, Daniel Bacon-Brown, Bill Martin, Ben Hastie. The Pharmaceutical Industry. major development in 1900’s Complexity Cost Drug discovery & development Controversy Current industry and direction…. Polymer-Drug Conjugates.

graham-coleman
Download Presentation

Polymers In Pharmaceuticals

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Polymers In Pharmaceuticals Makenzie Ball, Daniel Bacon-Brown, Bill Martin, Ben Hastie

  2. The Pharmaceutical Industry • major development in 1900’s • Complexity Cost • Drug discovery & development • Controversy • Current industry and direction…

  3. Polymer-Drug Conjugates • Defined as “nano-sized hybrid construct that covalently combine a bioactive agent with a polymer”. • Or, a polymer where some of the monomers act as drugs. • These can be used to significantly enhance the effect of drugs. Figure 1. Examples of polymer drug conjugates.

  4. Apoptosis • Defined as programmed cellular death. • Problems with the process cause: Alzheimers and Huntington’s diseases, ischemia, autoimmune disorders, and cancer. • Cancer drugs usually work by inducing apoptosis in the cancerous cells. • However, they also induce apoptosis in non-cancerous cells. This is why chemotherapy is so toxic.

  5. Use of polymer-drug conjugates to induce apoptosis for cancer treatments • Help target tumors because of their enhanced permeability and retention effect. • Improving drug activity. • Lowering drug toxicity. • TNP-470 is a conjugate that avoids causing harm to the brain because it’s polymeric aspect keeps it from crossing the blood brain barrier. Figure 2. Example of a polymer-drug conjugate.

  6. Marketing-Section Needs • Great need exist for “White Biotechnology” • White biotechnology is technology produced from natural enzymes that could be used to help provide fuel, refine agricultural crops, and help remove harmful products • Pharmaceuticals will benefit from white biotechnology in the form of antibotics

  7. Marketing-Section Needs • Another important need is in research and analyzing current production lines • 1st generation plants which generate current biotechnology, including antibiotics, are outdated • 2nd generation plants will be radically different • Current research in filtration shows vast improvements to current industrial practices • Research on carbon flux within cell will give crucial leads on engineering practices

  8. Pharmaceuticals Until 2020 • What major research activities will drive drug discovery and development? • Feed off research of biology, bioengineering, materials science, and nanotechnology • Holistic approach to combine diagnostics, drugs, and devices • What will the enabling technologies be? • Ultrafast computing microprocessor technology • Stem cell research • Nanotechnologies

  9. What paradigm shifts will there be in drug discovery, development, regulation and usage? • Current business model of discovery and development is unlikely to be sustainable with increased research and development costs with low yields • Realign from product to healthcare • Integration • Public-private development partnerships • Globalization • How will changes in education meet the demands of academia industry and regulatory institution? • New products means new technology • Life-long learning programs • Move from large lectures and laboratories to focus on small group teaching, problem solving tutorials and computer assisted learning • Become more pharmaceutical engineers

  10. Conclusion • Marketing • Emphasis on white biotechnology • Roadmap • Re-model business aspects of drug discovery/develop. • Specialized learning, more engineering • Current Technology • Efficiency of treatments could be better • Polymers and cancer

More Related