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Oral Anticoagulation and Preventing Stent Thrombosis

Oral Anticoagulation and Preventing Stent Thrombosis. Unadjusted Kaplan-Meier Survival Curves for STEMI vs NSTEMI. ATLAS ACS 2—TIMI 51: Rivaroxaban. All-cause mortality, non-fatal MI, non-fatal stroke, and severe recurrent ischemia (%); a ll patients received ASA +/- clopidogrel.

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Oral Anticoagulation and Preventing Stent Thrombosis

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  1. Oral Anticoagulation and Preventing Stent Thrombosis

  2. Unadjusted Kaplan-Meier Survival Curves for STEMI vs NSTEMI

  3. ATLAS ACS 2—TIMI 51: Rivaroxaban

  4. All-cause mortality, non-fatal MI, non-fatal stroke, and severe recurrent ischemia (%); all patients received ASA +/- clopidogrel

  5. Primary Safety Endpoint: Major and CRNM bleeding at 6 months

  6. Stent Thrombosis: ATLAS ACS 2—TIMI 51 and APPRAISE-2

  7. The Thrombin Paradox

  8. ATLAS ACS 2—TIMI 51: Mortality

  9. Abbreviations ACE = angiotensin-converting enzymeACS = acute coronary syndromeADP = adenosine diphosphateAF = atrial fibrillationAPPRAISE-2 = Apixaban for Prevention of Acute Ischemic Events 2aPC = activated protein CASA = aspirinATLAS ACS 2—TIMI 51 = Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Standard Therapy in Subjects with Acute Coronary Syndrome–Thrombolysis in Myocardial Infarction 51BID = twice dailyCI = confidence intervalCRNM = clinically relevant, non-majorCURE = Clopidogrel in Unstable Angina to Prevent Recurrent EventsDAPT = dual antiplatelet therapyESTEEM = Efficacy and Safety of the Oral Direct Thrombin Inhibitor Ximelagatran in Patients With Recent Myocardial DamageHR = hazard ratioi = inactiveISTH = International Society of Thrombosis and Haemostasis

  10. Abbreviations (cont)MI = myocardial infarctionNSTE-ACS = non-ST segment elevation acute coronary syndromeNSTEMI = non ST-segment elevation myocardial infarctionPAR-1 = protease-activated receptorQD = once dailyRE-DEEM = Randomized Dabigatran Etexilate Dose Finding Study in Patients With Acute Coronary Syndromes Post Index Event With Additional Risk Factors for Cardiovascular Complications Also Receiving Aspirin and Clopidogrel: Multi-centre, Prospective, Placebo Controlled, Cohort Dose Escalation StudyROCKET-AF = Rivaroxaban With Warfarin for the Prevention of Stroke and Non-Central Nervous System Systemic Embolism in Patients With Non-Valvular Atrial FibrillationRUBY-1 = Study Evaluating Safety, Tolerability and Efficacy of YM150 in Subjects With Acute Coronary SyndromesSTEMI = ST-segment elevation myocardial infarctionTF = tissue factor

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