Commitment & Efforts Toward Translational Science

1. Commitment & Efforts Toward Translational Science Subtitle Placeholder

2. To improve the health of our patients & community through innovation & excellence in care, education, research & service. Clarian’s Mission- 1997

3. To improve the health of our patients & community through innovation& excellence in care, education, research & service. Clarian’s Mission- 1997

4. IU Health Research Support • Annual support to IUSM for program development and strategic development • Hospital partner in CTSI development and operation • Alignment of Methodist Research Institute clinical trial unit within CTSI • IU Health Values Grants for Research & Education ($1.2 million/year) - focus on young investigators and pilot studies • IU-IRB infrastructure/operational support

5. IUH Research Support, cont’d • IU Health Annual Research Pillar Goal

6. Preeminence Framework

7. Preeminence Framework

9. Total admissions: 135,701 Total OP visits: 2,094,533 Total physicians: 3,707

10. Transformational & Pillar Goals • 2014 Transformational Goal: IU Health will be recognized as one of the nation’s leaders in hosting and supporting translational research, and in the development of personalized medicine, & clinical trials/participants across the system. • A key requirement will be a robust infrastructure, including IT. • 2011 Pillar Goal: Develop & implement system-wide IRB & biobank programs (target: 5375)

11. Clinical Trials: IT Support • For investigators: identification of potential trial candidates. • For patients: usable information about available clinical trials • For physicians: point-of-service information about potential patient-specific clinical trials

12. Biorepository patients • Mechanism established to allow IU Health submissions prior to completion of system-wide IU IRB (current total 1221) • System IU IRB project initial focus on Bloomington, Arnett, Ball. Target to be operational: July 2011. • Other IU Health facilities to be engaged on staggered basis.

13. IUSM-IU Health Joint Strategic Research Planning • Enterprise-wide research retreats (2010) • Establishment of broad-based Strategic Research Council • Development of a major Joint Aligned Strategic Plan for research (2011) • Aligned with key strategic service lines • Under leadership of David Wilkes, MD, Executive Associate Dean for Research, IUSM

14. Joint Strategic Research Proposal • Cancer • Center of Excellence in Cardiovascular Research • Neuroscience Research • Horizontal programs: IU Health Translational Postdoctoral Scholar Program; Faculty Retention Program. • Includes benchmarks, outcomes measures

15. Cancer • Pilot projects • Strategic recruitment • Statewide Clinical Research Office • Center for Chemical Biology and Drug Discovery

16. Cardiovascular Research • Basic and translational research in heart failure • Pharmacogenomics to promote drug efficacy and safety • Data Coordinating Center for Cardiovascular Outcomes Research

17. Neuroscience Research • Comprehensive Brain Injuries and Insults Research • Neurodegenerative Disorders Research • Neurodevelopmental Disorders Research

18. Joint Strategic Research Proposal Current Status

19. So...Why is IUH Committed to Enhancing Research? • It is a core component of our mission, and aligned with IUSM • It is a requisite for providing preeminent quality care for our patients • It extends the benefits beyond individuals, to also include the community and the next generation of our citizens and investigators

20. Thank you