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Noninvasive controlled abortion in the trimester of pregnancy ( a 15- years experience )

Noninvasive controlled abortion in the trimester of pregnancy ( a 15- years experience ). N . V .О rdzhonikidze , B . L. . Gurtovoi , N .М.Ка s а boulatov Research centre of Obstetrics , Gynecology & Perinatology Russian Academy of Medical Sciences High Risk Pregnancy Dept.

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Noninvasive controlled abortion in the trimester of pregnancy ( a 15- years experience )

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  1. Noninvasive controlled abortionin the trimester of pregnancy (a 15-years experience) N.V.Оrdzhonikidze, B.L..Gurtovoi, N.М.Каsаboulatov Research centre of Obstetrics, Gynecology & Perinatology Russian Academy of Medical Sciences High Risk Pregnancy Dept

  2. Main trends • Search for reasonable conservatism • Maximum safety • Limited operative intervention

  3. Objectives Elaboration of efficient method of late induced abortion with the purpose to enhance its safety and reduce complication rate.

  4. Stages of noninvasive controlled abortion in the II trimester • Maturation of the uterine cervix • Activation of contractions

  5. Neans of cervical maturation • Prostaglandins (cerviprost, prepidil-gel),intracervical,n=106 • Laminaria, intracervical, (dilapan) n=114 • Step by step combination of gel and laminaria (dilapan), n=80

  6. Means of uterine contractions • nalador-500 (sulproston-derivative of prostaglandin E2(«Schering», Germany), n=250 • prostin 15/М – derivative of prostaglandin F2-α («Updjohn»,USA), n=50

  7. M.S.Burnhill indexes before and after tretment

  8. Duration of abortion depending on the means of cervical maturation (hrs). 1-cerviprost, 2-laminaria, 3-combination

  9. Estradiol concentration in peripheral blood of women in the dynamics of late induced abortion (nmol/l) 1,2- before abortion 3-cervical maturation 4,5- progress of late abortion 6-miscarriage 7-first day after abortion

  10. Placental lactogene concentration in peripheral blood of women in the process of late induced abortion (nmol/l) 1,2-before abortion 3-cervical maturation 4,5-progress of late abortion 6-miscarriage 7-first day after abortion

  11. Cortisol concentration in peripheral blood of women in the dynamics of late induced abortion (nmol/l) 1,2-before abortion 3- cervical maturation 4,5-progress of late abortion 6-miscarriage 7-first day after abortion

  12. 17-а-oxiprogesteron concentration in peripheral blood of women in the dynamics of late induced abortion (nmol/l) 1,2- before abortion 3- cervical maturation 4,5-progress of late abortion 6-miscarriage 7-first day after abortion

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