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Schematic structure of the Au NR-based DOX and siRNA co-delivery nanocarriers .

Multifunctional Unimolecular Micelles for Targeted Cancer Therapy Shaoqin “Sarah” Gong, University of Wisconsin-Madison, DMR 1032187.

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Schematic structure of the Au NR-based DOX and siRNA co-delivery nanocarriers .

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  1. Multifunctional Unimolecular Micelles for Targeted Cancer TherapyShaoqin “Sarah” Gong, University of Wisconsin-Madison, DMR 1032187 • Tumor-targeting multifunctional Au nanorod (NR)-based nanocarriers capable of co-delivering anticancer drug (DOX) and siRNA were developed for targeted neuroendocrine cancer therapy. • The Au NR-based nanocarrier exhibits a pH-triggered drug release profile and excellent in vivo stability. • The cellular uptake of the OCT-conjugated Au nanocarrier was much higher than that of the non-targeted Au nanocarrier resulting from receptor-mediated endocytosis, thereby leading to much higher cytotoxicity. • OCT-conjugated Au nanocarriercomplexed with both DOX and ASCL1 siRNA demonstrated the highest cytotoxicity as well as ASCL1 silencing efficacy among the various Au nanocarriers tested. Hydrazonelinkage Polyethyleneglycol (PEG) Schematic structure of the Au NR-based DOX and siRNA co-delivery nanocarriers. Targeting ligands (OCT) Polyarginine (PLR) Anticancer drug (DOX) ASCL1 siRNA (siRNA) Gold nanorod(Au NR) Cytotoxicity of the various Au NR-based nanocarriers analyzed via the MTT assay. Expression of NET markers analyzed by Western blot.

  2. Multifunctional Unimolecular Micelles for Targeted Cancer TherapyShaoqin “Sarah” Gong, University of Wisconsin-Madison, DMR 1032187 • Cancer is the leading cause of death worldwide and the second leading cause of death in the U.S. More than 20,000 people die each day from various types of cancer. Because traditional chemotherapy is systemic, it can cause serious, undesirable side-effects and low treatment efficacy. • Nanotechnology can potentially revolutionize cancer therapy and diagnosis. Various nanoparticles--including liposomes, polymer micelles, and vesicles--have been studied as drug nanocarriers for targeted cancer therapy. One drawback with the most widely studied drug nanocarriers formed by self-assembly is their relatively poor in vivo stability due to their dynamic nature. • Anticancer drugs conjugated onto Au nanorodsvia pH-sensitive linkages can potentially provide excellent in vivo stability, which is highly desirable for targeted cancer therapy. • Tumor-targeted co-delivery of anticancer drug(s) and siRNA can potentially enhance the efficacy of cancer therapy significantly. • The resulting knowledge was integrated into a new course created by the PI related to Bio-Nano-Materials for the 2011 and 2012 Spring semesters. • Efforts were made to support researchers from underrepresented groups. • Both PIs’ labs have hosted high school students in recent years, including a female high school student this summer.

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