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Evolution of Experimental Design: A Historical Overview

Explore the historical development of experimental design from antiquity to modern times, including key milestones and influential figures in the field. From the early origins in Africa and the Fertile Crescent to the groundbreaking works of James Lind and Sir Ronald Fischer, uncover the evolution of experimental design principles and methodologies. Gain insights into randomization, optimal design, factorial experiments, and the future of designing simulation experiments. Discover the rich history that has shaped the field of experimental design today.

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Evolution of Experimental Design: A Historical Overview

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  1. EXPERIMENTAL DESIGNA historicalperspectiveLuc DuchateauGhent University

  2. Experimentation is as old as mankind • Out of Africa • FertileCrescent

  3. First account of “designed” experiment • James Lind (1747) • Assigntreatments in a random way toseamenwithscurvey

  4. Timeline Ethiopia: 1747 • End of golden age of GondarwithLyasu II

  5. First account of randomisationbasedinferenceandoptimal design • Charles Sanders Peirce (1876) • Semiotics

  6. First account of blindedrepeatedmeasures design • Charles Sanders Peirce (1885) • Toassesswhetherthereexists a leastperceptibledifference of excitations • “On small differences in sensation” Memoirs of the NAS 3, 73-83. Subject question: Is W2 smaller or larger than W1? W1 W1 W2

  7. Timeline Ethiopia: 1896 • Battle of Adwa: Menelik II

  8. First account of a collection of experimental designs • Sir Ronald Fischer • Arrangement of field experiments (1926) • Design of experiments (1935) • The geneticaltheory of naturalselection (1930) • Introduction of termssuch as • Blocking • Replication • Orthogonality • Factorial experiments

  9. Timeline Ethiopia: 1931 • EthiopianconstitutionstartedbyEmperorHaileSelassie

  10. First account of fractionalfactoralexperiments in industry • Plackett-Burman designs (1946)

  11. Broaddivision of experimental design • Encyclopedic • Randomised complete block • Latin square • Split plot • Fractional factorial • …. • Optimal • D-optimality • A-optimality …

  12. The future? • Designingsimulationexperiments

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