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Electronic Engineering Department Universitat Politècnica de Catalunya

Fast Electrical Impedance Spectroscopy measurement techniques for dynamic bioimpedance characterization. Ph.D. Student: B.Sánchez Thesis Advisor: R.Bragós. Electronic Engineering Department Universitat Politècnica de Catalunya. Contents. 1.- Introduction 2.- Motivation

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Electronic Engineering Department Universitat Politècnica de Catalunya

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  1. Fast Electrical Impedance Spectroscopy measurement techniques for dynamicbioimpedance characterization.Ph.D. Student: B.SánchezThesis Advisor: R.Bragós Electronic Engineering Department Universitat Politècnica de Catalunya

  2. Contents 1.- Introduction 2.- Motivation 3.- Multitone Burst Signal 4.- Results 5.- Conclusions

  3. Introduction Linear Time Invariant system: Impedance Transfer Function Laplace/Fourier Transform 1

  4. Ro |Z| R 8 f fc Introduction Biologicalsystems: Bioimpedance EquivalentCircuit Cellmembrane Extracellularmatrix LF HF 2

  5. Introduction Ex-vivo tissuecharacterization: 3

  6. Introduction In-vitro staticcellculturegrowthcharacterization: 4

  7. Motivation Challenge (I): In-vitro myocites cell culture growing characterization for tissue engineering applications Link video 5

  8. Motivation Challenge (II): In-vivo myocitespatchmonitoring and characterization: 6

  9. Multitone Burst Signals Time domain: 7

  10. Multitone Burst Signals Frequency domain: 8

  11. Multitone Burst Signals Crest Factor: Schroeder: Newman: Genetic Algorithm: 9

  12. Multitone Burst Signals Frequency Plan: Avoid intermodulation products: shift original tones for BW guard. 10

  13. Multitone Burst Signals Multitone bursts with Bilateral Quasi Logarithmic Frequency Distribution: 11

  14. Results Measurement Hardware Setup: • Custom FPGA based arbitrary signal generator. • DAC 12bits, 16Msamples, 40Ms/s, 1st order hold. • Ethernet capable controller. • PXI solution • PXI-5422: AWG, 200Ms/s, 32MB,16 bits. • PXIe-5122: AD 2channels, 100Ms/s, 64MB/channel, 14bits. • PXI-2530: multiplexation matrix, 128 channels. 12

  15. Results Yeast cell suspension settlement characterization: Estimation of the Growth Cell Curve 13

  16. Conclusions • Non invasive and non destructive technique for passive electrical properties charaterization of biological materials. • Valid measurement method for cell growth estimator and suitable for dynamic biological materials and systems characterization. • Wide application areas: electroporation, tomography, cell counting in microfludic, biosensors, tissue engineering,.. • The final application field is the cardiac tissue characterization in regenerative medicine applications. 14

  17. Fast Electrical Impedance Spectroscopy measurement techniques for dynamicbioimpedance characterization.Ph.D. Student: B.SánchezThesis Advisor: R.Bragós Electronic Engineering Department Universitat Politècnica de Catalunya

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