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MUSCLES!!. 3 Types of Muscles. Smooth Cardiac Skeletal. Smooth Muscle. No striations Single nucleus No/underdeveloped transverse tubules Involuntary Contracts in waves called peristalsis. Peristalsis. Educational: http://www.youtube.com/watch?v=o18UycWRsaA. Cardiac Muscle.
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3 Types of Muscles • Smooth • Cardiac • Skeletal
Smooth Muscle • No striations • Single nucleus • No/underdeveloped transverse tubules • Involuntary • Contracts in waves called peristalsis
Peristalsis • Educational: • http://www.youtube.com/watch?v=o18UycWRsaA
Cardiac Muscle • Like skeletal muscle but found only in the heart • Mononucleated • Involuntary • Well developed transverse tubule system • Contracts as a unit
Skeletal Muscles • Move bones at joints • Voluntary • Striated • Multiple nuclei • Transverse tubules systems– WELL DEVELOPED
Structure of a muscle Know this!
Myofilaments • Within each myofibril are myofilament. • Filaments: • Actin: Thin • Myosin: Thick • When a muscle contracts, actin slides past the myosin, shortening the sarcomere.
Tropomyosin-troponin complex • Calcium is like a key. • Tropomyosin is like a chain around your bike tires • Troponin is the lock attached to the chain. • The tires are the crossbridge of actin and myosin • The pedals are like ATP
Neuromuscular Junction • Where the terminal button of the motor neuron meets the motor endplate of the muscle. Includes the synaptic cleft. • Acetylcholine (ACh)is the neurotransmitter for muscles. • The synaptic vesicles release ACh into the synapse where it stimulates ACh receptors on the muscle fiber to begin contraction.
Sarcoplasmic reticulum releases calcium ions • Calcium binds to the actin filaments sites, opening them. • Myosin heads form cross bridges with actin at the binding site. • Cocked position -> Power stroke • ATP binds to cross bridge, releasing myosin from the actin • ATP breakdown provides energy to “cock” unattached myosin cross bridge. • Process repeats as long as there is ATP and calcium available.
Energy Supply • Myofibrils need oxygen for cellular respiration, which creates a lot of ATP. • Muscles can also use creatine phosphate to make ATP. • Glycolysis does not need oxygen but only makes a small amount of ATP. A by-product of this reaction is lactic acid.
Muscle Conditions • Muscle fatigue: Lactic acid build up • Muscle cramps: A lack of ATP. • Soreness : Rips in the muscle.
Slow oxidative twitch • Slow-oxidative twitch muscles have a protein called myoglobin which temporarily holds oxygen. This makes the muscle look dark or red. • That way, slow-oxidative twitch is used for aerobic long distance exercise.
Fast Twitch Glycolytic • Uses glycolysis. • White meat because few myoglobin proteins • Short distance, anaerobic • Less mitochondria
Fast twitch oxidative • In the middle of slow twitch oxidative and fast twitch glycolytic • Well vascularized • Pink meat
Types of Contractions • Isotonic: Change in length • Concentric: Shortening of the distance (flexing) • Excentric: Elongating muscle (extending) • Isometric: Change in force • Tetanus • Fused: Smooth contraction • Unfused: Shaky contraction
Disease • Myasthenia Gravis (MG): Autoimmune disorder that attacks receptors for ACh at neuromuscular junctions. • Symptoms: Abnormal muscle weakness (esp. facial muscles), chronic fatigue, trouble breathing
Things to ponder • Do all muscles have fascia? • Discuss with class