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Advancement of Science and Research on HIV

Advancement of Science and Research on HIV. Discussing past and future accomplishments of HIV research. Françoise BARR É-SINOUSSI Regulation of Retroviral Infections Unit Department of Virology. HIV/SIV Pathogenesis: Lessons from distinct outcome in Human & NHP. Natural Control.

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Advancement of Science and Research on HIV

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  1. Advancement of Science and Research on HIV Discussing past and future accomplishments of HIV research Françoise BARRÉ-SINOUSSI Regulation of Retroviral Infections Unit Department of Virology

  2. HIV/SIV Pathogenesis: Lessons from distinct outcome in Human & NHP Natural Control Acquired Control VNP HUMAN HAART, clinical trials VISCONTI patients EU LNTP HIC Berlin Patient Vaccinees (RV144…) HIV-2 AFRICAN Natural Host Pre-clinical studies for prevention and treatment…. ASIAN NHP SIC LNTP Vaccine studies (SIVmac239Nef…)

  3. HIV/SIV pathogenesis Adapted from G. Silvestri

  4. Early Response to HIV HIV Reservoirs Inflammation/Activation A.McMichael & B.Haynes, Nat. Rev.Immunol. 2010

  5. Early determinants of HIV pathogenesis • Viral reservoirs and HIV persistence: • Residual ongoing replication? • Survival/proliferation of TCM Inflammation and Chronic immune activation Host & Virus genetic polymorphism ? What do we need to consider to achieving control/protection? Innate & intrinsic immunity: pDC, NK antiviral activity, Restriction factors (APOBEC, TRIM5a,Tetherin, p21, Samhd1…) Adaptative immunity: Suppressive CD8 Tcell response (HICs), Nabs and other Ab functions, like ADCC…

  6. Discussing points • Need to identify the very, very first events and signals resulting in activation and viral persistence? Role of viral determinants? • Relevance of NHP models for studying these early mechanisms and how to control them? • Needs for additional models (primate models, humanized mice…) to identify correlates of protection against viral replication and/or viral acquisition?

  7. Long lasting protection against virus acquisition Will it be possible to develop a protective vaccine only based on Env immunogen? From J Mascola Peripheral vs mucosal immunity How to induce long term mucosal protective immunity?

  8. Learning beyond HIV… Cancer, lymphomas Cardiovascular diseases Ageing diseases Immune defects, Inflammatory and autoimmune maligancies ? ? Chronic HIV Infection on HAART

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