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Decisions. Transcribe gene. Splice RNA. Destroy protein. ..Or for the whole cell?. Think small, talk big. Sydney Brenner. lacZ. Cooperative Binding. Regulated Recruitment. Evolvability. Stepwise. 1.3. 1.3. 1.3. Evolvability. Synergy is easy. Evolvability. ‘New’ genes.
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Decisions Transcribe gene Splice RNA Destroy protein
Think small, talk big. Sydney Brenner
lacZ Cooperative Binding
Evolvability Stepwise
Evolvability Synergy is easy
Evolvability ‘New’ genes
The Price Specificity depends on concentration or sequestration
Recruiting Domains HTH HLH Zn Finger Winged Helix Homeodomain SH2 (P-Tyr) PTB (P-Tyr) SH3 (Pro) FHA (P-Thr) PH (PIP3)
A promoter …looks like a receptor