Introduction to the National Institutes of Health

1. Introduction to the National Institutes of Health Office of Science EducationNational Institutes of HealthDepartment of Health and Human Services

2. Administration for Children and Families (ACF) Administration on Aging (AoA) Agency for Healthcare Research and Quality (AHRQ) Agency for Toxic Substances & Disease Registry (ATSDR) Centers for Disease Control (CDC) Centers for Medicare and Medicaid Services (CMS) Food and Drug Administration (FDA) Indian Health Service (IHS) National Institutes of Health (NIH) Program Support Center (PSC) Substance Abuse & Mental Health Administration (SAMHSA) DHHS Agencies

4. NIAIDHamilton, MT NIA, NIDABaltimore, MD NIHBethesda, MD NIHBethesda, MD NIDDKPhoenix, AZ NIEHSRaleigh/Durham, NC NIEHSRaleigh/Durham, NC

5. Frederick, MD Frederick, MD Baltimore, MD Baltimore, MD Bethesda, MD Bethesda, MD

6. National Institutesof Health Bethesda, MD National Institutesof Health Bethesda, MD

7. The NIH has 75 buildings on 322 acres in Bethesda, Maryland

8. NIH is the steward of medical and behavioral research for the Nation. Its mission is science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability. The goals of the agency are as follows: 1) foster fundamental creative discoveries, innovative research strategies, and their applications as a basis to advance significantly the Nation's capacity to protect and improve health; 2) develop, maintain, and renew scientific human and physical resources that will assure the Nation's capability to prevent disease; 3) expand the knowledge base in medical and associated sciences in order to enhance the Nation's economic well-being and ensure a continued high return on the public investment in research; and 4) exemplify and promote the highest level of scientific integrity, public accountability, and social responsibility in the conduct of science. NIH Mission Statement

9. Organized into an Office of the Director & 27 Institutes and Centers 18,000+ employees Budget FY2003 27.173 Billion FY2004 28.028 Billion FY2005 28.757 Billion (President’s Budget) National Institutes of Health

10. NIH consists of 27 Institutes and Centers NHLBI NINR OD NCCAM NIEHS NCI NIAMS CIT NIDA NEI NIMH CC NIDDK NLM NINDS NHGRI NIDCR NCMHD NIBIB NIA NIDCD NIAAA NICHD NIAID CSR NCRR NIGMS FIC = Extramural only

11. National Institutes of Health The mission of the NIH is to uncover new knowledge that will lead to better health for everyone by: conducting research in its own laboratories (intramural) providing support for research conducted by scientists in universities, medical schools, hospitals, and other research institutions throughout the country and abroad (extramural) training research investigators fostering the communication of medical information

12. National Institutes of Health Budget (FY 2001 $20.3 billion) Research Management& Support 3% IntramuralResearch 10% Research Grants 71% All Other 6% R&DContracts 7% ResearchTraining3% Over 80% of NIH funds support extramural research

13. Warren Grant Magnuson Clinical Center The world’s largest hospital devoted exclusively to clinical research. 250 beds 7,000 inpatient admissions a year 9,750 new patients a year 72,600 outpatient visits a year 1,200 physicians, dentists, and doctoral-levelresearchers 900 active clinical research protocols

14. Mark O. Hatfield Clinical Research Center Opened September 2004

15. How many researchers are at NIH? 1,000 summer students (high school, college, graduate, and medical) 230 postbaccalaureate trainees 93 medical students 160 graduate students 3,300 postdoctoral and clinical fellows 287 tenure-track investigators 919 senior investigators (2001 data)

16. Nobel Laureates in the NIH Intramural Program Marshall W. Nirenberg, Ph.D., NHLBI (1968)Translated the genetic code of DNA and explained how it functions in the production of protein in the cell Julius Axelrod, Ph.D., NIMH (1970)Discovered the regulation of neurotransmitters, chemicals involved in nerve cell communication, leading to therapies for disorders like depression Christian B. Anfinsen, Ph.D., NIAMS (1972)Determined the relationship between the sequence of amino acids in proteins and their 3D structure

17. Nobel Laureates in the NIH Intramural Program (Cont’d) D. Carleton Gajdusek, M.D., NINDS (1976)Identified so-called slow viruses (now known as prions), which cause neurodegenerative diseases, and their mode of transmission Martin Rodbell, Ph.D., NIEHS (1994)Discovered “G” proteins which trigger a cell’s response to outside signals, involved in normal activities and in diseases like cancer and cholera

18. Distinguished scientists who trained at NIH Joseph L. Goldstein, M.D. andMichael S. Brown, M.D.Paul J. Thomas Professors of Medicine and Gentetics, University of Texas Health Science Center at Dallas, Nobel Laureates Philip Leder, M.D.John Emory Andrus Professor of Genetics at Harvard Medical School Harold E. Varmus, M.D.Director, Memorial Sloan-Kettering Cancer Center, Nobel Laureate, and former director of the NIH

19. NIH scientists in the news Francis S. Collins, M.D., Ph.D.Contributions to the success of the Human Genome Project Anthony S. Fauci, M.D. Award-winning research, recognized for his seminal research into AIDS and other immune system diseases

20. www.nih.gov