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Funded by: National Institutes of Health

Circulating Long-Chain ω -3 Fatty Acids and Incidence of Congestive Heart Failure in Older Adults: The Cardiovascular Health Study. Funded by: National Institutes of Health Dariush Mozaffarian , MD, DrPH ; et. al. Annals of Internal Medicine . 2011;155:160-170. Julianna L. Murphy

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Funded by: National Institutes of Health

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  1. Circulating Long-Chain ω-3 Fatty Acids and Incidence of Congestive Heart Failure in Older Adults: The Cardiovascular Health Study Funded by: National Institutes of Health DariushMozaffarian, MD, DrPH; et. al. Annals of Internal Medicine. 2011;155:160-170. Julianna L. Murphy Pharm.D. Candidate Preceptor: Ali Rahimi, MD, FACP-AGSF August 19, 2011

  2. Objective • To determine whether plasma phospholipid concentrations of long-chain ω-3 fatty acids, including eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), were associated with incident CHF.

  3. ω-3 Fatty Acids • Essential fatty acids • Reduce inflammation • May reduce risk for chronic diseases, including heart disease • Have also been used for: • Dyslipidemia • Hypertension • Diabetes mellitus

  4. Study Design and Patient Population • Multicenter, prospective cohort • Conducted over a 13-year period • 5,888 ambulatory, non-institutionalized adults recruited in 4 U.S. communities • 2,735 participants analyzed • All data collected from 1992 to 1993 visit and blood sample • Standardized procedure for CHF confirmation

  5. Participant Criteria • Age 65+ years • Within the 4 recruitment communities • Exclusions: • Diagnosed CHF at time of enrollment • Presence of coronary heart disease or other serious cardiovascular illness

  6. Measurements and Outcome • Plasma phospholipid fatty acid concentrations measured in 1992 samples • Relationships with incident CHF assessed using Cox proportional hazards models • Other cardiovascular risk factors were similarly analyzed

  7. Results • Plasma EPA concentration inversely associated with CHF, with hazard ratio (HR) of 0.52 • Lower risk trends also found with DPA (HR = 0.76) and total ω-3 fatty acid levels (HR = 0.70) • DHA levels not found to be inversely associated with incident CHF

  8. Results

  9. Conclusion • Higher levels of circulating ω-3 fatty acids are associated with a lower incidence of congestive heart failure in older adults

  10. Comments • Limitations • Fatty acid concentrations measured only once • Possible presence of additional confounders • Study sample only from 4 communities in the United States • Dietary recall performed once, at time of enrollment

  11. Level of Evidence/Grade of Recommendation • Level IIb • Grade B

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