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The Evolution of Cytochrome P450 in Animals David R. Nelson

The Evolution of Cytochrome P450 in Animals David R. Nelson University of Tennessee Dept. of Molecular Sciences Center of Excellence in Genomics and Bioinformatics. Drug Metabolism in humans

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The Evolution of Cytochrome P450 in Animals David R. Nelson

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  1. The Evolution of Cytochrome P450 in Animals David R. Nelson University of Tennessee Dept. of Molecular Sciences Center of Excellence in Genomics and Bioinformatics

  2. Drug Metabolism in humans CYP3A4/3A5, CYP2D6, CYP2C9 ~75% + CYP2C19, CYP2E1, CYP1A2, CYP2A6 90-95%

  3. Metazoan Genomes Sampler

  4. Halocynthia roretzi adult and larva Cnidarian Chordate Porifera (sponges) Suberites domuncula leech (annelid worm) plus hermit crab

  5. 3 Clan UPGMA tree of 4 Clan Hydra P450s 2 Clan

  6. CYP21 11A1 11-Deoxycorticosterone 11B1 Corticosterone CYP17 CYP17 11B2 Aldosterone CYP21 CYP17 CYP17 11-Deoxdycortisol 11B1 CYP19 Cortisol

  7. CYP51 UPGMA tree of Amphioxus CYPs (not mito clan) CYP7/39 Clan CYP20 CYP26 Clan CYP4 Clan CYP3 Clan CYP19 CYP2 Clan

  8. 24 26 27 CYP27A1 1 CYP2R1 CYP27B1 CYP24 active form inactive

  9. CYP24 Neighbor-joining tree of amphioxus mito clan P450s CYP11 CYP27

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