Labile or stable: opposing consequences for memory when reactivated during waking and sleep

1. Labile or stable: opposing consequences for memory when reactivated during waking and sleep Susanne Diekelmann, Christian Büchel, Jan Born & Björn Rasch Feng Jingyu

2. Memory Consolidation Consolidation is defined as a time-dependent stabilizationprocess that leads eventually to the permanentstorage of newly acquired memory

3. Reactivation & Reconsolidation Memories are not consolidated, or stabilized,just once: they can return to a labile state and need to bereconsolidated, or restabilized, when reactivated

5. Experimental procedures 1.Participants learned object-location task in presence of the experimental odor 2.One group of subjects stayed awake.The other group of subjects went to sleep 3.learned an interference object-location task 4.Recall of the original object-location task was tested 30 min after interference learning (Each participant was also tested in a control condition in which, instead of odor, odorless vehicle was presented during waking and SWS, respectively)

6. Results

7. Results

8. Conclusion • Reactivation during waking destabilized memory traces, returning them to a labile state, • The same odor-cued reactivation stabilized memory traces when induced during SWS

9. Neuronal correlates of reactivation during waking

10. Old memory Retrival Rminder Active memory New situations Overwritten memory Reconsolidated memory

11. Neuronal correlates of reactivation during waking

12. Neuronal correlates of reactivation duringSWS

13. Reactivation during SWS stablization or Newly encoded memory Strengthened memory transient destabilization fast restabilization To be continued

14. Thank you