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Inference of Genealogies for Recombinant SNP Sequences in Populations

Suffix. Prefix. 11000. 0000001111. Breakpoint. Inference of Genealogies for Recombinant SNP Sequences in Populations. 110001111111001. Yufeng Wu Computer Science and Engineering Department University of Connecticut. 000110000001111.

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Inference of Genealogies for Recombinant SNP Sequences in Populations

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  1. Suffix Prefix 11000 0000001111 Breakpoint Inference of Genealogies for Recombinant SNP Sequences in Populations 110001111111001 Yufeng Wu Computer Science and Engineering Department University of Connecticut 000110000001111 Recombination: One of the principle genetic forces shaping sequence variations within species

  2. 00 1 0 0 1 10 1 1 Genealogical History with Recombination Mutations Recombination 10 01 00 10 11 01 00 S1 = 00 S2 = 01 S3 = 10 S4 = 11 Assumption: At most one mutation per site S1 = 00 S2 = 01 S3 = 10 S4 = 10

  3. Possible Disease mutation At which Marginal Tree Did Disease Mutations Occur? Use of inferred genealogical history in mapping complex traits Case Control

  4. Research Topics related to Recombination • Estimate the level of recombination in genomic regions. • Infer the genealogical history with recombination. • Mapping causative loci for complex traits using inferred genealogical history • Computation of likelihood and estimation of population genetic parameters. Research supported by NSF and UConn Research Foundation.

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