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The Research Question

This study explores the relationship between cardiovascular risk and statin use in the United States. The researchers found that hyperlipidemia, rather than cardiovascular risk, is most strongly associated with statin users. This highlights the need to refocus statin use from solely lowering cholesterol to reducing cardiovascular events and mortality. Getting more high-risk individuals on statins can save lives.

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The Research Question

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  1. The Research Question Does Cardiovascular Risk Predict Statin Use? Michael Johansen MD MS, Ohio State University, Lee Green MD MPH, Ananda Sen PhD, Sheetal Kircher MD MS, Caroline Richardson MD MS.  • Cardiovascular Risk and Statin Use in the United States. Ann Fam Med. (In Press) • The Question: Does cardiovascular risk predict statin use? • Why this is important? • Statins are highly efficacious in reducing death in individuals with high cardiovascular risk

  2. What the Researchers Did • Adults between 30-79 • Cross-sectional study utilizing the nationally representative Medical Expenditure Panel Survey (MEPS). • Basic Method/Intervention • Determine the proportion of individuals who were on a statin (2 or more prescriptions in a year) • Stratify by risk profiles • Determine clinical conditions associated with use.

  3. What the Researchers Found • 58% of individuals with reported coronary artery disease and 52% of individuals with diabetes over age 40 reported statin use. • Hyperlipidemia, not cardiovascular risk, is most strongly associated with statin users.

  4. What This Means for Clinical Practice • There are large numbers of individuals with coronary artery disease and/or diabetes that benefit from statins who are not taking them. • Getting more high-risk people on statins will save lives. • Refocus statin use from being a cholesterol lowering medication to one that reduces cardiovascular events and mortality.

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