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Events,. Events,. %. Authors. OR (95% CI). RR (95% CI). Treatment. Cases. Control. Weight. Aggerholm et al., 2008. 1.05 (0.17, 6.65). 1.05 (0.17, 6.65). 1/8. 1/8. 103/868. 1.37. Braga et al., 2012. 0.50 (0.09, 2.92). 0.50 (0.09, 2.92). 1/5. 1/5. 50/125. 1.49.
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Events, Events, % Authors OR (95% CI) RR (95% CI) Treatment Cases Control Weight Aggerholm et al., 2008 1.05 (0.17, 6.65) 1.05 (0.17, 6.65) 1/8 1/8 103/868 1.37 Braga et al., 2012 0.50 (0.09, 2.92) 0.50 (0.09, 2.92) 1/5 1/5 50/125 1.49 Duits et al., 2009 0.81 (0.13, 4.85) 0.81 (0.13, 4.85) 1/6 1/6 137/662 1.44 Eskandar et al., 2012 1.49 (0.70, 3.18) 1.49 (0.70, 3.18) 12/54 12/54 10/67 7.93 Hammiche et al., 2012 0.57 (0.10, 3.31) 0.57 (0.10, 3.31) 1/5 1/5 54/153 1.49 Jensen et al., 2004 0.94 (0.69, 1.30) 0.94 (0.69, 1.30) 23/55 23/55 533/1204 40.61 Keltz et al., 2010 & Relwani et al., 2011 1.70 (0.71, 4.06) 1.70 (0.71, 4.06) 1/1 1/1 18/41 6.07 Koloszar et al., 2005 & Fejes et al., 2005 & Fejes et al., 2006 1.64 (1.01, 2.66) 1.64 (1.01, 2.66) 13/30 13/30 42/159 18.81 Li et al., 2009 0.82 (0.37, 1.82) 0.82 (0.37, 1.82) 6/92 6/92 79/991 7.12 Ramlau-Hansen et al., 2009 1.40 (0.52, 3.76) 1.40 (0.52, 3.76) 3/10 3/10 40/187 4.75 Shayeb et al., 2011 0.35 (0.05, 2.34) 0.35 (0.05, 2.34) 1/17 1/17 136/802 1.28 Vujkovic et al., 2009 & Hammiche et al., 2011 0.34 (0.03, 4.30) 0.34 (0.03, 4.30) 0/2 0/2 50/102 0.72 Lévy et al., unpublished 1.96 (0.87, 4.42) 1.96 (0.87, 4.42) 2/3 2/3 111/326 6.91 Overall (I-squared = 2.0%, p = 0.426) 1.15 (0.93, 1.43) 1.15 (0.93, 1.43) 65/288 65/288 1363/5687 100.00 .0269 1 1 37.2 Lower prevalence in underweight Higher prevalence in underweight
Events, Events, % Authors RR (95% CI) OR (95% CI) Cases Treatment Control Weight Aggerholm et al., 2008 1.18 (0.91, 1.53) 1.18 (0.91, 1.53) 92/657 92/657 103/868 6.67 Braga et al., 2012 0.65 (0.44, 0.96) 0.65 (0.44, 0.96) 26/100 26/100 50/125 3.99 Chavarro et al., 2009 1.20 (0.61, 2.36) 1.20 (0.61, 2.36) 25/233 25/233 11/123 1.67 Duits et al., 2009 1.09 (0.88, 1.34) 1.09 (0.88, 1.34) 132/587 132/587 137/662 8.19 Eskandar et al., 2012 1.06 (0.52, 2.15) 1.06 (0.52, 2.15) 19/120 19/120 10/67 1.55 Eskenazi et al., 2003 2.39 (0.89, 6.43) 2.39 (0.89, 6.43) 10/41 10/41 5/49 0.83 Hammiche et al., 2012 1.24 (0.96, 1.61) 1.24 (0.96, 1.61) 97/221 97/221 54/153 6.69 Jensen et al., 2004 1.16 (1.01, 1.33) 1.16 (1.01, 1.33) 123/240 123/240 533/1204 10.81 Keltz et al., 2010 & Relwani et al., 2011 0.99 (0.65, 1.51) 0.99 (0.65, 1.51) 38/87 38/87 18/41 3.64 Koloszar et al., 2005 & Fejes et al., 2005 & Fejes et al., 2006 1.11 (0.78, 1.59) 1.11 (0.78, 1.59) 45/153 45/153 42/159 4.58 La Vignera et al., 2012 3.00 (1.65, 5.46) 3.00 (1.65, 5.46) 30/50 30/50 10/50 2.06 Li et al., 2009 1.36 (0.90, 2.08) 1.36 (0.90, 2.08) 26/239 26/239 79/991 3.64 Lotti et al., 2011 1.06 (0.85, 1.33) 1.06 (0.85, 1.33) 45/71 45/71 78/131 7.72 Magnusdottir et al., 2005 0.81 (0.30, 2.22) 0.81 (0.30, 2.22) 6/32 6/32 6/26 0.80 Martini et al., 2010 1.10 (0.95, 1.28) 1.10 (0.95, 1.28) 218/392 218/392 124/246 10.30 Ramlau-Hansen et al., 2009 0.91 (0.48, 1.75) 0.91 (0.48, 1.75) 9/46 9/46 40/187 1.80 Shayeb et al., 2011 1.10 (0.89, 1.35) 1.10 (0.89, 1.35) 164/883 164/883 136/802 8.37 Tunc et al., 2011 2.46 (0.79, 7.66) 2.46 (0.79, 7.66) 13/37 13/37 3/21 0.64 Vujkovic et al., 2009 & Hammiche et al., 2011 0.66 (0.47, 0.93) 0.66 (0.47, 0.93) 33/102 33/102 50/102 4.83 Zorn et al., 2007 & Zorn et al., 2012 1.14 (0.71, 1.84) 1.14 (0.71, 1.84) 25/79 25/79 23/83 3.01 Lévy et al., unpublished 1.15 (0.93, 1.42) 1.15 (0.93, 1.42) 109/279 109/279 111/326 8.22 Overall (I-squared = 41.6%, p = 0.024) 1.11 (1.01, 1.21) 1.11 (1.01, 1.21) 1285/4649 1285/4649 1623/6416 100.00 .131 1 1 7.66 Lower prevalence in overweight Higher prevalence in overweight
Events, Events, % Authors OR (95% CI) RR (95% CI) Cases Treatment Control Weight Aggerholm et al., 2008 0.62 (0.33, 1.16) 0.62 (0.33, 1.16) 10/135 10/135 103/868 4.47 Braga et al., 2012 0.50 (0.14, 1.76) 0.50 (0.14, 1.76) 2/10 2/10 50/125 1.81 Chavarro et al., 2009 1.26 (0.59, 2.71) 1.26 (0.59, 2.71) 13/115 13/115 11/123 3.61 Duits et al., 2009 2.24 (1.77, 2.83) 2.24 (1.77, 2.83) 63/136 63/136 137/662 7.60 Eskandar et al., 2012 1.06 (0.53, 2.12) 1.06 (0.53, 2.12) 21/133 21/133 10/67 4.01 Eskenazi et al., 2003 1.40 (0.19, 10.30) 1.40 (0.19, 10.30) 1/7 1/7 5/49 0.82 Hammiche et al., 2012 1.29 (0.92, 1.81) 1.29 (0.92, 1.81) 31/68 31/68 54/153 6.77 Jensen et al., 2004 1.15 (0.88, 1.49) 1.15 (0.88, 1.49) 29/57 29/57 533/1204 7.38 Keltz et al., 2010 & Relwani et al., 2011 1.05 (0.67, 1.65) 1.05 (0.67, 1.65) 25/54 25/54 18/41 5.80 Koloszar et al., 2005 & Fejes et al., 2005 & Fejes et al., 2006 1.67 (1.19, 2.35) 1.67 (1.19, 2.35) 46/104 46/104 42/159 6.76 La Vignera et al., 2012 2.50 (1.32, 4.72) 2.50 (1.32, 4.72) 20/40 20/40 10/50 4.39 Li et al., 2009 1.57 (0.42, 5.83) 1.57 (0.42, 5.83) 2/16 2/16 79/991 1.69 Lotti et al., 2011 0.50 (0.25, 1.00) 0.50 (0.25, 1.00) 6/20 6/20 78/131 4.07 Magnusdottir et al., 2005 3.94 (1.91, 8.14) 3.94 (1.91, 8.14) 10/11 10/11 6/26 3.81 Martini et al., 2010 1.11 (0.92, 1.35) 1.11 (0.92, 1.35) 82/146 82/146 124/246 7.91 Ramlau-Hansen et al., 2009 0.88 (0.30, 2.52) 0.88 (0.30, 2.52) 3/16 3/16 40/187 2.35 Shayeb et al., 2011 1.22 (0.92, 1.63) 1.22 (0.92, 1.63) 51/246 51/246 136/802 7.17 Tunc et al., 2011 2.13 (0.63, 7.19) 2.13 (0.63, 7.19) 7/23 7/23 3/21 1.90 Vujkovic et al., 2009 & Hammiche et al., 2011 0.97 (0.58, 1.62) 0.97 (0.58, 1.62) 9/19 9/19 50/102 5.28 Zorn et al., 2007 & Zorn et al., 2012 2.14 (1.34, 3.41) 2.14 (1.34, 3.41) 16/27 16/27 23/83 5.65 Lévy et al., unpublished 0.88 (0.62, 1.23) 0.88 (0.62, 1.23) 29/97 29/97 111/326 6.74 Overall (I-squared = 70.6%, p = 0.000) 1.28 (1.06, 1.55) 1.28 (1.06, 1.55) 476/1480 476/1480 1623/6416 100.00 .0971 1 1 10.3 Lower prevalence in obese Higher prevalence in obese
Events, Events, % OR (95% CI) RR (95% CI) Treatment Cases Control Weight Authors Aggerholm et al., 2008 2.10 (0.19, 23.31) 2.10 (0.19, 23.31) 0/1 0/1 103/868 1.03 Braga et al., 2012 1.75 (1.11, 2.77) 1.75 (1.11, 2.77) 7/10 7/10 50/125 12.88 Chavarro et al., 2009 2.80 (0.90, 8.66) 2.80 (0.90, 8.66) 3/12 3/12 11/123 4.02 Duits et al., 2009 0.48 (0.07, 3.12) 0.48 (0.07, 3.12) 1/10 1/10 137/662 1.66 Eskandar et al., 2012 4.79 (2.67, 8.57) 4.79 (2.67, 8.57) 90/126 90/126 10/67 10.18 Hammiche et al., 2012 1.42 (0.35, 5.76) 1.42 (0.35, 5.76) 1/2 1/2 54/153 2.79 Jensen et al., 2004 1.13 (0.28, 4.52) 1.13 (0.28, 4.52) 1/2 1/2 533/1204 2.84 Keltz et al., 2010 & Relwani et al., 2011 1.14 (0.27, 4.75) 1.14 (0.27, 4.75) 1/2 1/2 18/41 2.70 Koloszar et al., 2005 & Fejes et al., 2005 & Fejes et al., 2006 2.38 (1.62, 3.52) 2.38 (1.62, 3.52) 17/27 17/27 42/159 14.69 La Vignera et al., 2012 3.00 (1.42, 6.35) 3.00 (1.42, 6.35) 6/10 6/10 10/50 7.45 Magnusdottir et al., 2005 0.52 (0.04, 7.56) 0.52 (0.04, 7.56) 0/3 0/3 6/26 0.84 Martini et al., 2010 1.88 (1.56, 2.28) 1.88 (1.56, 2.28) 9/9 9/9 124/246 20.18 Shayeb et al., 2011 1.97 (1.00, 3.85) 1.97 (1.00, 3.85) 6/18 6/18 136/802 8.62 Lévy et al., unpublished 1.47 (0.82, 2.64) 1.47 (0.82, 2.64) 6/12 6/12 111/326 10.12 Overall (I-squared = 42.7%, p = 0.046) 2.04 (1.59, 2.62) 2.04 (1.59, 2.62) 148/244 148/244 1345/4852 100.00 .0357 1 1 28 Lower prevalence in morbid obese Higher prevalence in morbid obese
Events, Events, % RR (95% CI) OR (95% CI) Cases Treatment Control Weight Authors General population Aggerholm et al., 2008 1.08 (0.84, 1.40) 1.08 (0.84, 1.40) 102/793 102/793 103/868 6.34 Eskenazi et al., 2003 2.25 (0.84, 5.98) 2.25 (0.84, 5.98) 11/48 11/48 5/49 0.95 Jensen et al., 2004 1.16 (1.02, 1.31) 1.16 (1.02, 1.31) 153/299 153/299 533/1204 9.26 La Vignera et al., 2012 2.80 (1.57, 5.01) 2.80 (1.57, 5.01) 56/100 56/100 10/50 2.32 Li et al., 2009 1.38 (0.92, 2.07) 1.38 (0.92, 2.07) 28/255 28/255 79/991 3.85 Ramlau-Hansen et al., 2009 0.90 (0.51, 1.61) 0.90 (0.51, 1.61) 12/62 12/62 40/187 2.34 Subtotal (I-squared = 58.9%, p = 0.033) 1.30 (1.03, 1.65) 1.30 (1.03, 1.65) 362/1557 362/1557 770/3349 25.07 . Infertile population Braga et al., 2012 0.73 (0.51, 1.04) 0.73 (0.51, 1.04) 35/120 35/120 50/125 4.63 Chavarro et al., 2009 1.27 (0.68, 2.40) 1.27 (0.68, 2.40) 41/360 41/360 11/123 2.02 Duits et al., 2009 1.29 (1.07, 1.56) 1.29 (1.07, 1.56) 196/733 196/733 137/662 7.79 Eskandar et al., 2012 2.30 (1.28, 4.14) 2.30 (1.28, 4.14) 130/379 130/379 10/67 2.27 Hammiche et al., 2012 1.26 (0.98, 1.61) 1.26 (0.98, 1.61) 129/291 129/291 54/153 6.47 Keltz et al., 2010 & Relwani et al., 2011 1.02 (0.69, 1.51) 1.02 (0.69, 1.51) 64/143 64/143 18/41 4.08 1.44 (1.07, 1.94) 1.44 (1.07, 1.94) 108/284 108/284 42/159 5.51 Koloszar et al., 2005 & Fejes et al., 2005 & Fejes et al., 2006 Lotti et al., 2011 0.94 (0.75, 1.19) 0.94 (0.75, 1.19) 51/91 51/91 78/131 6.90 Magnusdottir et al., 2005 1.51 (0.67, 3.37) 1.51 (0.67, 3.37) 16/46 16/46 6/26 1.34 Martini et al., 2010 1.12 (0.97, 1.29) 1.12 (0.97, 1.29) 309/547 309/547 124/246 8.89 Shayeb et al., 2011 1.14 (0.94, 1.38) 1.14 (0.94, 1.38) 221/1147 221/1147 136/802 7.73 Tunc et al., 2011 2.33 (0.77, 7.06) 2.33 (0.77, 7.06) 20/60 20/60 3/21 0.76 Vujkovic et al., 2009 & Hammiche et al., 2011 0.71 (0.52, 0.97) 0.71 (0.52, 0.97) 42/121 42/121 50/102 5.23 Zorn et al., 2007 & Zorn et al., 2012 1.40 (0.92, 2.13) 1.40 (0.92, 2.13) 41/106 41/106 23/83 3.69 Lévy et al., unpublished 1.09 (0.89, 1.33) 1.09 (0.89, 1.33) 144/388 144/388 111/326 7.61 Subtotal (I-squared = 55.8%, p = 0.004) 1.13 (1.01, 1.27) 1.13 (1.01, 1.27) 1547/4816 1547/4816 853/3067 74.93 . Overall (I-squared = 55.1%, p = 0.001) 1.17 (1.06, 1.29) 1.17 (1.06, 1.29) 1909/6373 1909/6373 1623/6416 100.00 .142 1 1 7.06 Lower prevalence in abnormal weight Higher prevalence in in abnormal weight