Breast Cancer Research

1. Breast Cancer Research Michael J Kerin| Professor of Surgery & Research Director, NBCRI Breast Cancer Research, School of Medicine

2. NCRI Predictions 2005-2035Breast Cancer Incidence in Ireland 4833 1771 2010-2030: 53% increase in incidence 3484  623 2781  137 2196 Breast Cancer Research, School of Medicine

3. Total No. of Breast Cancer Cases 2003-2010 University Hospital Galway Breast Cancer Research, School of Medicine

4. Symptomatic Breast Clinic 2009 Annual Report • 2003-2009: number of patients attending the unit increased from 3475 to 9671 • Breast cancer diagnoses increased from 110 to 529 per annum • 2005-2009: 61-68% of women have been treated with breast conservation surgery • 61% of women were given a a post-mastectomy immediate breast reconstruction Breast Cancer Research, School of Medicine

5. UHG Breast Clinic Team Breast Cancer Research, School of Medicine

6. Breast Cancer Research • Laboratory established by Professor Fred Given in 1991 • National Breast Cancer Research Institute (NBCRI) charity funding has enabled research development • Comprehensive specimens biobank and database chaptering over 20 years of patients • National & international scientific and clinical collaborators Breast Cancer Research, School of Medicine

7. Core Research Projects

8. Postgraduate & Undergraduate Researchers 2005-2011 70% of our student researchers are partially or fully funded by NBCRI Breast Cancer Research, School of Medicine

9. Molecular Profiling:CancerGenes Research Questions? What genes are involved in causing breast cancer? Are genes affected by chemotherapy, radiotherapy etc? Can we develop a cancer gene profile that will improve diagnosis and treatment of breast cancer? Breast Cancer Research, School of Medicine

10. Gene & Cell Therapy:Adult Stem Cells • Stem cells have the potential to develop into many different cell types in the body • Do they develop into cancer cells? • Can they be used to target cancer cells? • Can cells “home” to bone, lungs? Breast Cancer Research, School of Medicine

11. MicroRNA & Gene Profiling Research Team Nicola Miller PhD Research Supervisor • Breast Cancer • Dr Aoife Lowery PhD • Dr Helen Heneghan • Dr Nuala Healy • Dr Ailbhe McDermott • Dr Ronan Glynn • Colorectal Cancer • Dr Kah Hoong Chang • Dr Mary Nugent • Prostate Cancer • Dr Brian Kelly Breast Cancer Research, School of Medicine

12. Stem Cells & Tumour Microenvironment Research Team • Roisin Dwyer PhD • Research Supervisor • Sonja Khan MSc • James Ryan MSc • Dr Shirley Potter • Dr Marion Hartmann • Dr Fiachra Martin • Dr John Kelly Breast Cancer Research, School of Medicine

13. Population Genetics Research Team • Nicola Miller PhD Research Supervisor • Breast Cancer • Dr Niall McInerney • Dr Gabrielle Colleran • Dr Jemima Dorairaj Breast Cancer Research, School of Medicine

14. Breast Cancer Management Research Article published Sept 2009 How has the clinical management of breast cancer changed? Minimally invasive diagnostic techniques, screening Breast Conserving Surgery Sentinel Lymph Node Biopsy Oncoplastics & Reconstruction Molecular Biology Research Breast Cancer Research, School of Medicine

15. Recent High Impact Publications Stem CellsJune 2011 (REMEDI, Arizona, Mayo Clinic Collaboration) The Lancet Oncology, March 2011 (Yale Collaboration) Breast Cancer Research, School of Medicine

16. Recent High Impact Publications JNCI, December 2010 (Oxford Collaboration) Breast Cancer Research, School of Medicine

17. International Impact of Publishing Research Clinical Cancer Research 2007 Cited by 91 other studies Annals of Surgery, March 2010 50 citations Breast Cancer Research, School of Medicine

18. Clinical and Preclinical Trials • Irish Cooperative Research Group (ICORG) Trial opened in May 2011 Investigating the effect of neoadjuvant therapy on microRNA expression in breast cancer • Preclinical Translational Trials in Animal Models We are translating what we have found in the lab to an in vivo model. The animal facility is based in REMEDI, NUI Galway. Strict ethical guidelines regulate this field of research Breast Cancer Research, School of Medicine

19. Research Collaborators International • Yale University, USA (Dr Frank Slack) • University of Arizona (Dr Harrison Barrett) • The Mayo Clinic, US (Dr John Morris) • University of Oxford (Prof Ian Tomlinson, Dr Ellie Sawyer) • European Molecular Biology Laboratory, Germany (Dr Vladimir Benes) • Nottingham Trent University, UK (Dr Graham Ball) • Baylor University, Texas (Kent Osborne, Rachel Schiff) National • Biomedical Diagnostic Institutes, DCU Local • Molecular Diagnostic Research Group, NUI Galway (Dr. Tom Barry) • REMEDI, NUI Galway (Prof Tim O’Brien, Prof Frank Barry) • Clinical Research Facility Biostatistics Unit (Dr John Newell) Breast Cancer Research, School of Medicine

20. Funding Income 2004-2011 Breast Cancer Research, School of Medicine

21. Recent Funding Awards Breast Cancer Campaign, UK • €100,000 (2011-2015) SFI Biomedical Diagnostic Institute • €400,000 (2011-2015) • Postdoctoral Scientist and Research Assistant employed in April 2011 in collaboration with Molecular Diagnostics Research Group Breast Cancer Research, School of Medicine

22. How your money is spent Breast Cancer Research, School of Medicine

23. UHG Clinical Breast Service Breast Research Facilities Breast Cancer Research, School of Medicine

24. Translation Research Facility:Breast Cancer Research for the Future Cois Coiribe 2009: NUI Galway Alumni Publication Architect image of TRF. To be located on UHG campus Breast Cancer Research, School of Medicine

25. Breast Cancer Biobank • Collection of patient specimens and data that may be used for research • Ethically approved • Patient Consent • Largest breast cancer biobank in Ireland • Over 4000 patients registered • Multiple specimens per patient Breast Cancer Research, School of Medicine

26. Fundraising Groups: Friends of NBCRI • Galway – Anna O’Coinne • Mullingar – Joe Duffy • Dublin – Goretti Newell, Miriam Hand • Sligo – Oonagh Monahan • Ennis – Monica Gallagher • Castlebar –Lourda McHugh • ICA, ILGU, Jim Bolger Breast Cancer Research, School of Medicine

27. NBCRI Fundraising Events Into the West Cycle (Mullingar to Galway…and back!) Breast Cancer Research, School of Medicine

28. Cois Cladaigh Christmas Concert • December 2010 • Tea at the GOct 2010(Afternoon Tea/Fashion Show) Breast Cancer Research, School of Medicine

29. NBCRI Fundraising Events California Walking Challenge 2010 2011 Destinations Sweden (July) New York (November) Breast Cancer Research, School of Medicine

30. Other NBCRI Fundraising Events • National Sponsored Cycles, Walks, Marathons • Table Quizzes, Race nights • Fashion shows • Coffee mornings, lunches • Supermarket bag pack • Car Wash • Golf AM-AM • Gala Dinners (e.g. Valentine’s Ball, Galway) • Auctions • Record breaking – Get in the Guinness Book of Records and help breast cancer Research! Breast Cancer Research, School of Medicine

31. For more information… Website @ www.nbcri.ie Research Newsletter 2011 Breast Cancer Research, School of Medicine

32. Radical Mastectomy Fisher NSABP CMFCAF 1900 Taxotere 1970 1980 Molecular Classification Simple Mastectomy 2010 Tamoxifen Her2neu

33. Future Developments • Breast Cancer care will continue to improve with individualisation of therapy • High volume unit improves patient outcomes • Enhanced specialist expertise of next generation by combining science and medicine for patient benefit • Local and National Research Collaborators • Quality International Research Output from West of Ireland Breast Cancer Research, School of Medicine