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LPS

P<0.001. 2 00. Caspase-1 activity (% of control). 150. *. 100. -. +. +. +. LPS. -. +. +. +. P = 0.01. ATP. -. -. -. +. 600. 16673-34-0. Cell death (% of control). -. -. -. Intermediate compound. +. 400. *. 200. 1 00.

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LPS

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  1. P<0.001 200 Caspase-1 activity (% of control) 150 * 100 - + + + LPS - + + + P=0.01 ATP - - - + 600 16673-34-0 Cell death (% of control) - - - Intermediate compound + 400 * 200 100 Supplemental Figure 1. An 16673-34-0 intermediate lacking that sulfonyl residue has no inhibitory effects on the NLRP3 inflammasome

  2. Survival (after surgery) 16673-34-0 100 90 80 70 60 Vehicle only 50 40 30 Glyburide) P<0.001 20 10 24 72 48 Hours Supplemental Figure 2. Effects of glyburide or 16673-34-0 on survival after ischemia-reperfusion surgery.

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