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Workflow: understanding and representing complex biological data TO analysis of that data TO discoveries made through th

Workflow: understanding and representing complex biological data TO analysis of that data TO discoveries made through that analysis. Understand the scope and complexity of the data. Understand the experiment and the subsequent curation to understand the errors. Understand how

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Workflow: understanding and representing complex biological data TO analysis of that data TO discoveries made through th

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  1. Workflow: understanding and representing complex biological data TO analysis of that data TO discoveries made through that analysis Understand the scope and complexity of the data Understand the experiment and the subsequent curation to understand the errors Understand how to best represent the data Identify relationships In the data Recognize redundancy In the data Classify the data Explore algorithms that analyze the data Make new biological discoveries from the data PHAR201 2012 Course Outline

  2. But What Does it Mean Pragmatically? • Details of macromolecular structure • Consider the experiments used to derive structure • Ontologies • Sequence-structure-function relationships • Structure classification • Algorithms to compare structures • Algorithms to define domains • Hot topics: Disorder • Hot topics: Structure-based PPIs • Hot topics: Drug discovery through structure and systems biology • Hot topics: Evolution studied through structure PHAR201 2012 Course Outline

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