Circulatory System Functions and Regulation

1. Chapter Goals After studying this chapter, students should be able to . . . 1. describe the general functions of the major components of the circulatory system. 2. describe the structures and pathways of the pulmonary and systemic circulations. 3. compare the structure of an artery and vein, and explain how the structure of each type of vessel relates to its function. 4. describe the structure of capillaries and explain the physiological significance of this structure. 5. explain how atherosclerosis may develop and comment on the significance of this condition. 6. describe the components and functions of the lymphatic system. 7. define cardiac output and describe how it is affected by cardiac rate and stroke volume 8. explain how autonomic nerves regulate the cardiac rate and the strength of ventricular contraction

2. Chapter Goals After studying this chapter, students should be able to . . . 9. explain the intrinsic regulation of stroke volume (the Frank-Starling law of the heart) 10. list the factors that affect the venous return of blood to the heart 11. explain how tissue fluid is formed and how it is returned to the capillary blood 12. explain how edema may be produced 13. explain how antidiuretic hormone helps to regulate the blood volume, plasma osmolality, and the blood pressure 14. explain the role of aldosterone in the regulation of blood volume and pressure 15. describe the renin-angiotensin system and its significance in cardiovascular regulation 16. use Poiseuille's law to explain how blood flow is regulated 17. define total peripheral resistance, and explain how vascular resistance is regulated by extrinsic control mechanisms

3. Chapter Goals 18. describe the intrinsic mechanisms involved in the autoregulation of blood flow 19. explain the mechanisms by which blood flow to the heart and skeletal muscles is regulated 20. describe the changes that occur in the cardiac output and in the distribution of blood flow in the body during exercise 21. describe the factors that regulate the arterial blood pressure 22. describe the baroreceptor reflex and explain its significance in blood pressure regulation 23. explain how the sounds of Korotkoff are produced and how these sounds are used to measure blood pressure 24. describe how the pulse pressure and mean arterial pressure are calculated and explain the significance of these measurements 25. explain the mechanisms that contribute to and that help compensate for the conditions of hypertension, circulatory shock, and congestive heart failure

4. IV. CIRCULATION • Hemodynamics • Capillary Dynamics • Lymphatics • Special Areas

5. Hemodynamics • Cardiac output • Venous return • Circulation

6. Cardiac Output • Cardiac Output = Heart Rate X Stroke Volume • a. If HR = 70 b/m and SV = 70 mL/b, then CO = 70 x 70 = 4,900 mL/m • b. If CO = 4,900 mL/m and SV = 100 mL/b, then HR = 4,900/100 = 49 b/m

7. Cardiac Output (cont’d) • c. Since physical conditioning results in a greater SV, then HR is less for any given CO. The only time the heart muscle itself receives blood and nourishment is during diastole, and the slower HR the more time the heart spends in diastole. So physical conditioning allows a longer time for the heart to receive nourishment with each cardiac cycle.

8. Cardiac Output (cont’d) • d. Starling's Law -- The force with which a muscle contracts is proportional to the initial length of the contracting fibers. 9-26

9. Venous Return a. Valves b. “Skeletal Muscle Pump” c. Low peripheral resistance d. "Thoracic pump"

10. 10-29

11. 10-30

12. 10-32

13. 10-34

14. Circulation • Volume of Flow • Effect of Pressure and Resistance on Flow F(vol) = rP/R

15. 10-2

16. 10-11

17. Circulation • Volume of Flow • Poiseuille's Law F(vol) = prP(r)4/8hL Where h = Viscosity

18. 10-3

19. 13.23

20. 10-9

21. Cardiac Control (cont’d) 10-37

22. Circulation (cont’d) • Velocity of Flow F(vel)= 1/cross-sectional area • i. Aorta = 50 cm/sec • ii. Capillaries = 0.06 cm/sec

23. 10-16

24. 10-18a

25. 10-18b

26. Circulation (cont’d) • Regulation of Flow • Chemical • Metabolites (CO2 & Lactic Acid —>dilation) • Tissue hypoxia —> adenosine —> dilation • Neural : epinephrine —> vasoconstriction

27. 10-14

28. Circulation (cont’d) • Blood Pressure • Types • Pulse Pressure = Systolic Pressure - Diastolic Pressure • Mean Pressure - Average during one cardiac cycle = D + 1/3(S - D) or D + 1/3 Pulse pressure • Arterial Blood Pressure - Pressure in a large artery • Regulation

29. 10-36

30. 10-35

31. 10-19

32. Capillary Dynamics 10-23

33. Lymphatics • Since there is normally a net filtration pressure in capillaries, the lymphatic vessels return the fluid filtered to the blood stream. Vessels begin as blind capillaries, which eventually empty into the subclavian veins. Lymph is propelled by the same factors that aid venous return

34. 10-25a

35. 10-25b

36. 10-26

37. 13.34

38. Special Areas 1. Coronary - Heart receives only during diastole 2. Pulmonary - Low resistance results in low pressure, so there is a net reabsorption pressure in pulmonary capillaries, which keeps the pulmonary membrane thin and, thus, aids gas exchange. 3. Cerebral - Circle of Willis maintains blood flow to both sides of the brain, even if a blood vessel proximal to the circle is blocked

39. Chapter Summary Blood Vessels I. Arteries contain three layers, or tunics: the interna, media, and externa. A. The tunica interna consists of a layer of endothelium, which is separated from the tunica media by a band of elastin fibers. B. The tunica media consists of smooth muscle. C. The tunica externa is the outermost layer. D. Large arteries, containing many layers of elastin can expand and recoil with rising and falling blood pressure. Medium and small arteries and arterioles are less distensible, and thus provide greater resistance to blood flow. II. Capillaries are the narrowest but the most numerous of the blood vessels. A. Capillary walls consist of just one layer of endothelial cells. They provide for the exchange of molecules between the blood and the surrounding tissues. B. The flow of blood from arterioles to capillaries is regulated by precapillary sphincter muscles. C. The capillary wall may be continuous, fenestrated, or discontinuous.

40. Chapter Summary III. Veins have the same three tunics as arteries, but they generally have a thinner muscular layer than comparably sized arteries. A. Veins are more distensible than arteries and can expand to hold a larger quantity of blood. B. Many veins have venous valves that ensure a one-way flow of blood to the heart. C. The flow of blood back to the heart is aided by contraction of the skeletal muscles that surround veins. The effects of this action is called the skeletal muscle pump.

41. Chapter Summary Atherosclerosis and Cardiac Arrhythmias I. Atherosclerosis of arteries can occlude blood flow to the heart and brain, causing up to 50% of all mortality in the United States, Europe, and Japan. A. Atherosclerosis begins with injury to the endothelium, the movement of monocytes and lymphocytes into the tunica interna, and the conversion of monocytes into macrophages that engulf lipids. Smooth muscle cells then proliferate and secrete extracellular matrix. B. Atherosclerosis is promoted by smoking, hypertension, and high plasma cholesterol concentration, among other risk factors; low-density lipoproteins (LDL), which carry cholesterol into the artery wall, is oxidized by the endothelium and is a major contributor to atherosclerosis. II. Occlusion of blood flow in the coronary arteries by atherosclerosis may produce ischemia of the heart muscle and angina pectoris, which may lead to myocardial infarction. III. The ECG can be used to detect abnormal cardiac rates, abnormal conduction between the atria and ventricles, and other abnormal patterns of electrical conduction in the heart.

42. Chapter Summary Lymphatic System I. Lymphatic capillaries are blind-ended but highly permeable. They drain excess tissue fluid into lymph ducts. II. Lymph passes through lymph nodes and is returned by way of the lymph ducts to the venous blood.

43. Chapter Summary Cardiac Output I. Cardiac rate is increased by sympathoadrenal stimulation and decreased by the effects of parasympathetic fibers that innervate the SA node. II. Stroke volume is regulated both extrinsically and intrinsically. A. The Frank-Starling law of the heart describes the way the end-diastolic volume, through various degrees of myocardial stretching, influences the contraction strength of the myocardium and thus the stroke volume. B. The end-diastolic volume is called the preload. The total peripheral resistance, through its effect on arterial blood pressure, provides an afterload that acts to reduce the stroke volume. C. At a given end-diastolic volume, the amount of blood ejected depends on contractility. Strength of contraction is increased by sympathoadrenal stimulation. III. The venous return of blood to the heart is dependent largely on the total blood volume and mechanisms that improve the flow of blood in the veins. A. The total blood volume is regulated by the kidneys. B. The venous flow of blood to the heart is aided by the action of skeletal muscle pumps and the effects of breathing.

44. Chapter Summary Blood Volume I. Tissue fluid is formed from and returns to the blood. A. The hydrostatic pressure of the blood forces fluid from the arteriolar ends of capillaries into the interstitial spaces of the tissues. B. Since the colloid osmotic pressure of plasma is greater than tissue fluid, water returns by osmosis to the venular ends of capillaries. C. Excess tissue fluid is returned to the venous system by lymphatic vessels. D. Edema occurs when there is an accumulation of tissue fluid. II. The kidneys control the blood volume by regulating the amount of filtered fluid that will be reabsorbed. A. Antidiuretic hormone stimulates reabsorption of water from the kidney filtrate and thus acts to maintain the blood volume. B. A decrease in blood flow through the kidneys activates the renin-angiotensin system. C. Angiotensin II stimulates vasoconstriction and the secretion of aldosterone by the adrenal cortex. D. Aldosterone acts on the kidneys to promote the retention of salt and water.

45. Chapter Summary Vascular Resistance and Blood Flow I. According to Poiseuille's law, blood flow is directly related to the pressure difference between the two ends of a vessel and is inversely related to the resistance to blood flow through the vessel. II. Extrinsic regulation of vascular resistance is provided mainly by the sympathetic nervous system, which stimulates vasoconstriction of arterioles in the viscera and skin. III. Intrinsic control of vascular resistance allows organs to autoregulate their own blood flow rates. A. Myogenic regulation occurs when vessels constrict or dilate as a direct response to a rise or fall in blood pressure. B. Metabolic regulation occurs when vessels dilate in response to the local chemical environment within the organ.

46. Chapter Summary Blood Flow to the Heart and Skeletal Muscles I. The heart normally respires aerobically because of its high capillary supply, myoglobin content, and enzyme content. II. During exercise, when the heart's metabolism increases, intrinsic metabolic mechanisms stimulate vasodilation of the coronary vessels and thus increase coronary blood flow. III. Just prior to exercise and at the start of exercise, blood flow through skeletal muscles increases due to vasodilation caused by cholinergic sympathetic nerve fibers. During exercise, intrinsic metabolic vasodilation occurs. IV. Since cardiac output can increase by a factor of five or more during exercise, the heart and skeletal muscles receive an increased proportion of a higher total blood flow. A. The cardiac rate increases due to lower activity of the vagus nerve and higher activity of the sympathetic nerve. B. The venous return is greater because of higher activity of the skeletal muscle pumps and increased breathing. C. Increased contractility of the heart, combined with a decrease in total peripheral resistance, can result in a higher stroke volume.

47. Chapter Summary Blood Flow to the Brain and Skin I. Cerebral blood flow is regulated both myogenically and metabolically. A. Cerebral vessels automatically constrict if the systemic blood pressure rises too high. B. Metabolic products cause local vessels to dilate and supply more active areas with more blood. II. The skin has unique arteriovenous anastomoses, which can shunt the blood away from surface capillary loops when body temperature rises. A. The activity of sympathetic nerve fibers causes constriction of cutaneous arterioles. B. As a thermoregulatory response, there is increased cutaneous blood flow and increased flow through surface capillary loops when the body temperature rises.

48. Chapter Summary Blood Pressure I. Baroreceptors in the aortic arch and carotid sinuses affect, via the sympathetic nervous system, the cardiac rate and the total peripheral resistance. A. The baroreceptor reflex causes pressure to be maintained when an upright posture is assumed. This reflex can cause a lowered pressure when the carotid sinuses are massaged. B. Other mechanisms that affect blood volume help to regulate blood pressure. II. Blood pressure is commonly measured indirectly by auscultation of the brachial artery when a pressure cuff is inflated and deflated. A. The first sound of Korotkoff, caused by turbulent flow of blood through a constriction in the artery, occurs when the cuff pressure equals the systolic pressure. B. The last sound of Korotkoff is heard when the cuff pressure equals the diastolic blood pressure. III. The mean arterial pressure represents the driving force for blood flow through the arterial system.

49. Chapter Summary Hypertension, Shock, and Congestive Heart Failure I. Hypertension, or high blood pressure, is classified as either primary or secondary. A. Primary hypertension, also called essential hypertension, may be the result of the interaction of many mechanisms that raise the blood volume, cardiac output, and/or peripheral resistance. B. Secondary hypertension is the direct result of known, specific diseases. II. Circulatory shock occurs when there is inadequate delivery of oxygen to the organs of the body. A. In hypovolemic shock, low blood volume causes low blood pressure that may progress to an irreversible state. B. The fall in blood volume and pressure stimulates various reflexes that produce a rise in cardiac rate, shift of fluid from the tissues into the vascular system, decrease in urine volume, and vasoconstriction. III. Congestive heart failure occurs when the cardiac output is insufficient to supply the blood flow required by the body. The term congestive is used to describe the increased venous volume and pressure that results.