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DNA Replication: Seeing Double

DNA Replication: Seeing Double. Mr. Nichols PHHS. Cartoons of the Days!. Cartoons of the Days!. Cartoons of the Days!. Cartoons of the Days!. If you were in charge…. How would you start to replication the DNA in front of you? . How it’s really done. Step 1 of DNA Replication:

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DNA Replication: Seeing Double

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  1. DNA Replication: Seeing Double Mr. NicholsPHHS

  2. Cartoons of the Days!

  3. Cartoons of the Days!

  4. Cartoons of the Days!

  5. Cartoons of the Days!

  6. If you were in charge…. • How would you start to replication the DNA in front of you?

  7. How it’s really done. • Step 1 of DNA Replication: • An enzyme called “Helicase,” comes in and breaks the hydrogen bonds pulling the two DNA strands apart. • The separated DNA molecule is called a “Replication fork.” • Create a “Helicase” on a sheet of paper and show this step with you desk models.

  8. What does this look like? Replication Fork

  9. Step 2 of DNA Replication • Another enzyme called “DNA Polymerase I,” attaches itself to one of the separated strands of DNA. • Once attached DNA Polymerase I starts to copy the DNA strand by attaching the missing parts of the base pair. • The strand that DNA Polymerase I attaches to is called the “Leading strand.”

  10. What does this look like? • Model this step with your partner, create a DNA Polymerase I on a separate sheet of paper to use in this step.

  11. What should this look like?

  12. Step 3 of DNA Replication • The other strand is then copied by yet another enzyme called “DNA Polymerase II,” this adds the complimentary base pair. • The strand that DNA Polymerase II attaches to is called the “Lagging Strand.” • Create a DNA polymerase II on a piece of paper and model this with your partner.

  13. Step 4 of DNA Replication • Once DNA Polymerase I and II are finished copying the Leading and Lagging strands two complete strands of DNA separate from one another. • When the two DNA molecules separate a molecule called Telomeres attach to the ends of the DNA and cap them to ensure the Bases don’t shift around. • Create Telomeres out of paper and model this step.

  14. What this step looks like with when finished

  15. Step 5 of DNA Replication • Enzymes called nucleases come in and double check that the DNA was copied properly. • If the nucleases find and error they either fix the problem directly or have other cell machinery to do so. • What could’ve gone wrong in this process?

  16. Review and Assess • With your notes and your partner, conduct this entire process of start to finish.

  17. Cartoons of the Day!

  18. Cartoons of the Day!

  19. Cartoons of the Day!

  20. Cartoons of the Day!

  21. Cartoons of the Day!

  22. Cartoons of the Day!

  23. Cartoons of the Day!

  24. Cartoons of the Day!

  25. Cartoons of the Day!

  26. Quote of the Day! • “For every fact there is an infinity of hypotheses.” • ~Robert M. Pirsig

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